Antiretroviral Therapy Adherence and Secondary Prevention of Human Immunodeficiency Virus
| Status: | Active, not recruiting |
|---|---|
| Conditions: | HIV / AIDS |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/21/2019 |
| Start Date: | November 2012 |
| End Date: | April 2019 |
In this study, investigators propose to randomize 165 human immunodeficiency virus positive
patients to one of three 16-week treatment conditions: (1) standard care; (2) standard care +
cell phone-based adherence reminders; or (3) standard care + cell phone-based adherence
reminders and contingency management. In this latter condition, patients will earn
reinforcement for sending in time- and date-stamped self videos of antiretroviral therapy
medication ingestion. Primary outcomes will include viral loads and self-report measures of
adherence, and effects will be evaluated both during the treatment period and throughout a
one-year follow-up. Investigators hypothesize that the cell phone reminder condition will
improve adherence relative to standard care, and the cell phone reminder plus contingency
management condition will have the best outcomes. Results from this study may have widespread
implications for the use of cell phones as a novel technology to improve initial adherence to
antiretroviral therapy, thereby reducing the spread of drug resistant human immunodeficiency
virus strains to the community.
patients to one of three 16-week treatment conditions: (1) standard care; (2) standard care +
cell phone-based adherence reminders; or (3) standard care + cell phone-based adherence
reminders and contingency management. In this latter condition, patients will earn
reinforcement for sending in time- and date-stamped self videos of antiretroviral therapy
medication ingestion. Primary outcomes will include viral loads and self-report measures of
adherence, and effects will be evaluated both during the treatment period and throughout a
one-year follow-up. Investigators hypothesize that the cell phone reminder condition will
improve adherence relative to standard care, and the cell phone reminder plus contingency
management condition will have the best outcomes. Results from this study may have widespread
implications for the use of cell phones as a novel technology to improve initial adherence to
antiretroviral therapy, thereby reducing the spread of drug resistant human immunodeficiency
virus strains to the community.
Inclusion Criteria:
- age > 18 years
- initiating or on an antiretroviral therapy regimen and have a viral load >200
copies/mL in the past 6 months
- one or more risk factors for poor adherence
- English speaking
- willing to use a cell phone to receive reminders and record medication ingestion for
up to 16 weeks
- able to read at 5th grade level and pass a brief quiz related to understanding the
informed consent form
Exclusion Criteria:
- living in an environment or has a visiting nurse that dispenses antiretroviral therapy
medication
- participating in another antiretroviral therapy adherence study
- uncontrolled psychiatric disorders
- significant cognitive impairment
We found this trial at
2
sites
263 Farmington Ave
Farmington, Connecticut 06030
Farmington, Connecticut 06030
(860) 679-2000
Principal Investigator: Nancy M Petry, Ph.D.
Phone: 860-679-4556
University of Connecticut Health Center UConn Health is a vibrant, integrated academic medical center that...
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New Haven, Connecticut 06520
Principal Investigator: Merceditas Villanueva, M.D.
Phone: 860-679-4556
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