Oral Antibiotics After 2-Stage Revision for Infected Total Hip Arthroplasty and Total Knee Arthroplasty

Status:	Recruiting
Conditions:	Infectious Disease, Orthopedic
Therapuetic Areas:	Immunology / Infectious Diseases, Orthopedics / Podiatry
Healthy:	No
Age Range:	18 - 90
Updated:	6/10/2018
Start Date:	July 2011
End Date:	December 2020
Contact:	Craig J Della Valle, MD
Email:	craigdv@yahoo.com
Phone:	3124322350

The Utility of Oral Antibiotic Therapy Following 2-stage Revision Arthroplasty for Infected Prosthetic Hips and Knees

The primary purpose of this study is to compare the re-infection rates in patients undergoing
2-stage revision arthroplasty who receive additional oral antibiotic therapy to those
patients who received in-hospital perioperative antibiotic only. Patients will be monitored
for re-infection following hospital discharge, defined as deep infection of the joint
space/capsule that requires return to the operating room within 24-months of the
re-implantation procedure.

Inclusion criteria:

Adult patients undergoing 2-stage revision arthroplasty of the knee or hip with the
causative organism(s) identified using tissue culture and/or joint fluid analysis that is
amenable to oral antibiotic therapy. Patients must be able to tolerate oral antibiotics and
agree to participate in the study.

Exclusion criteria:

Patients with a fungal prosthetic joint infection, unable to tolerate or refuse to undergo
oral antibiotic therapy, unable to follow-up at the specified intervals, allergic to the
therapy of preference, or have an organism that is not amenable to oral antibiotic therapy.

We found this trial at

sites

Rothman Institute

Philadelphia, Pennsylvania 19107

Principal Investigator: Javad Parvizi, MD, FRCS

1225

from

Philadelphia, PA