A Study to Evaluate the Effects of Calcium Carbonate and Ferrous Fumarate on Pharmacokinetics of Dolutegravir in Healthy Adult Subjects

Inclusion Criteria:

- Healthy as determined by a responsible and experienced physician, based on a medical
evaluation including medical history, physical examination, laboratory tests and ECG.

- Male or female between 18 and 65 years of age inclusive, at the time of signing the
informed consent.

- A female subject is eligible to participate if she is of: non-childbearing potential,
or child-bearing potential and agrees to use one of the contraception methods for an
appropriate period of time prior to the start of dosing to sufficiently minimize the
risk of pregnancy at that point. Female subjects must agree to use contraception
until the follow-up visit.

- Body weight >= 50 kilogram (kg) for males and >=45 kg for females and body mass index
(BMI) within the range 18.5 to 31.0 kg/meter^2 (inclusive).

- Alanine aminotransferase (ALT), alkaline phosphatase and bilirubin <=1.5xupper limit
of normal (ULN) (isolated bilirubin >1.5xULN is acceptable if bilirubin is
fractionated and direct bilirubin <35%).

- Single QT interval corrected using Fredericia's formula (QTcF) <450 millisecond
(msec)

- Capable of giving written informed consent, which includes compliance with the
requirements and restrictions listed in the consent form.

Exclusion Criteria:

- A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody
result within 3 months of screening.

- The subject has a positive pre-study drug/alcohol screen. A minimum list of drugs
that will be screened for include amphetamines, barbiturates, cocaine, opiates,
cannabinoids and benzodiazepines.

- A positive test for HIV antibody.

- Where participation in the study would result in donation of blood or blood products
in excess of 500 mL within a 56 day period.

- Pregnant females as determined by positive serum or urine human chorionic
gonadotropin test at screening or prior to dosing.

- Lactating females.

- Current or chronic history of liver disease, or known hepatic or biliary
abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones).

- History of regular alcohol consumption within 6 months of the study defined as an
average weekly intake of >14 drinks for males or >7 drinks for females. One drink is
equivalent to 12 gram of alcohol =12 ounces (360 mL) of beer, 5 ounces (150 mL) of
wine or 1.5 ounces (45 mL) of 80 proof distilled spirits.

- The subject has participated in a clinical trial and has received an investigational
product within the following time period prior to the first dosing day in the current
study: 30 days, 5 half-lives or twice the duration of the biological effect of the
investigational product (whichever is longer).

- Unable to refrain from the use of prescription or non-prescription drugs, including
vitamins, herbal and dietary supplements (including St John's Wort) within 7 days (or
14 days if the drug is a potential enzyme inducer) or 5 half-lives (whichever is
longer) prior to the first dose of study medication, unless in the opinion of the
Investigator and GlaxoSmithKline (GSK) Medical Monitor the medication will not
interfere with the study procedures or compromise subject safety.

- History of sensitivity to any of the study medications, or components thereof or a
history of drug or other allergy that, in the opinion of the investigator or GSK
Medical Monitor, contraindicates their participation.

- Unwillingness or inability to follow the procedures outlined in the protocol

- Subject is mentally or legally incapacitated.

- If heparin is used during PK sampling, subjects with a history of sensitivity to
heparin or heparin-induced thrombocytopenia should not be enrolled.

- Consumption of red wine, Seville oranges, grapefruit or grapefruit juice from 7 days
prior to the first dose of study medication.

- Unwillingness or inability to follow the procedures in the protocol.

- The subject's systolic blood pressure is outside the range of 90-140 millimeter
mercury (mmHg, or diastolic blood pressure is outside the range of 45 to 90 mmHg or
heart rate is outside the range of 50-100 beats per minutes (bpm) for female subjects
or 45 to 100 bpm for male subjects. A single repeat is allowed for eligibility
determination.

- Exclusion criteria for screening ECG (a single repeat is allowed for eligibility
determination): Male subjects with Heart rate <45 and >110 bpm and female subjects
with heart rate <50 and >100 bpm, PR <120 and >220 milliseconds (msec), QRS duration
<70 and >120 msec, QTc (Bazett) >450 msec.

- Evidence of previous myocardial infarction (does not include ST segment changes
associated with repolarization).

- Any conduction abnormality (including but not specific to left or right complete
bundle branch block, AV block [2nd degree or higher], Wolf Parkinson White [WPW]
syndrome), non-sustained or sustained ventricular tachycardia (>=3 consecutive
ventricular ectopic beats), and sinus pauses > 3 seconds.

- Any significant arrhythmia which, in the opinion of the principal investigator and
GSK medical monitor, will interfere with the safety for the individual subject.