Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk



Status:Completed
Conditions:High Cholesterol, Peripheral Vascular Disease
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:40 - 85
Updated:2/17/2018
Start Date:February 8, 2013
End Date:November 11, 2016

Use our guide to learn which trials are right for you!

Trial Summary
Trial Overview
Inclusion Criteria

A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing the Impact of Additional LDL-Cholesterol Reduction on Major Cardiovascular Events When Evolocumab (AMG 145) is Used in Combination With Statin Therapy In Patients With Clinically Evident Cardiovascular Disease

The primary objective was to evaluate the effect of treatment with evolocumab, compared with
placebo, on the risk for cardiovascular death, myocardial infarction, stroke, hospitalization
for unstable angina, or coronary revascularization, whichever occurs first, in patients with
clinically evident cardiovascular disease.


Inclusion Criteria:

- Male or female ≥ 40 to ≤ 85 years of age

- History of clinically evident cardiovascular disease at high risk for a recurrent
event

- Fasting low-density lipoprotein cholesterol (LDL-C) ≥ 70 mg/dL (≥ 1.8 mmol/L) ) or
non-high-density lipoprotein cholesterol (non-HDL-C) ≥ 100 mg/dL (> 2.6 mmol/L)

- Fasting triglycerides ≤ 400 mg/dL (4.5 mmol/L)

Exclusion Criteria:

- New York Heart Association (NYHA) class III or IV, or last known left ventricular
ejection fraction < 30%

- Uncontrolled hypertension

- Uncontrolled or recurrent ventricular tachycardia

- Untreated hyperthyroidism or hypothyroidism

- Homozygous familial hypercholesterolemia

- LDL or plasma apheresis
We found this trial at
331
sites
Clinical Trial Facility in Sacramento California
Sacramento, California 95825
?
mi
from
Sacramento, CA
Click here to add this to my saved trials
Clinical Trial Facility in Abington Pennsylvania
Abington, Pennsylvania 19001
?
mi
from
Abington, PA
Click here to add this to my saved trials
Clinical Trial Facility in Addison Illinois
Addison, Illinois
?
mi
from
Addison, IL
Click here to add this to my saved trials
Clinical Trial Facility in Albany New York
Albany, New York 12205
?
mi
from
Albany, NY
Click here to add this to my saved trials
Clinical Trial Facility in Alhambra California
Alhambra, California 91801
?
mi
from
Alhambra, CA
Click here to add this to my saved trials
Clinical Trial Facility in Altoona Pennsylvania
Altoona, Pennsylvania 16602
?
mi
from
Altoona, PA
Click here to add this to my saved trials
Clinical Trial Facility in Ames Iowa
Ames, Iowa 50010
?
mi
from
Ames, IA
Click here to add this to my saved trials
Clinical Trial Facility in Anchorage Alaska
Anchorage, Alaska
?
mi
from
Anchorage, AK
Click here to add this to my saved trials
Clinical Trial Facility in Anderson South Carolina
Anderson, South Carolina
?
mi
from
Anderson, SC
Click here to add this to my saved trials
Clinical Trial Facility in Ann Arbor Michigan
Ann Arbor, Michigan 48109
?
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
Clinical Trial Facility in Annapolis Maryland
Annapolis, Maryland 21401
?
mi
from
Annapolis, MD
Click here to add this to my saved trials
Clinical Trial Facility in Arlington Texas
Arlington, Texas 76017
?
mi
from
Arlington, TX
Click here to add this to my saved trials
Clinical Trial Facility in Asheville North Carolina
Asheville, North Carolina
?
mi
from
Asheville, NC
Click here to add this to my saved trials
Clinical Trial Facility in Asheville North Carolina
Asheville, North Carolina
?
mi
from
Asheville, NC
Click here to add this to my saved trials
Clinical Trial Facility in Athens Georgia
Athens, Georgia 30607
?
mi
from
Athens, GA
Click here to add this to my saved trials
Clinical Trial Facility in Atlanta Georgia
Atlanta, Georgia
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Clinical Trial Facility in Atlanta Georgia
Atlanta, Georgia
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Clinical Trial Facility in Atlantis Florida
Atlantis, Florida
?
mi
from
Atlantis, FL
Click here to add this to my saved trials
Clinical Trial Facility in Auburn Maine
Auburn, Maine 04210
?
mi
from
Auburn, ME
Click here to add this to my saved trials
Clinical Trial Facility in Augusta Georgia
Augusta, Georgia 30912
?
mi
from
Augusta, GA
Click here to add this to my saved trials
Clinical Trial Facility in Aurora Colorado
Aurora, Colorado 80045
?
mi
from
Aurora, CO
Click here to add this to my saved trials
Clinical Trial Facility in Austin Texas
Austin, Texas 78744
?
mi
from
Austin, TX
Click here to add this to my saved trials
Clinical Trial Facility in Aventura Florida
Aventura, Florida 33108
?
mi
from
Aventura, FL
Click here to add this to my saved trials
Clinical Trial Facility in Ayer Massachusetts
Ayer, Massachusetts
?
mi
from
Ayer, MA
Click here to add this to my saved trials
Clinical Trial Facility in Bahia Blanca Buenos Aires
Bahia Blanca, Buenos Aires
?
mi
from
Bahia Blanca,
Click here to add this to my saved trials
Clinical Trial Facility in Baltimore Maryland
Baltimore, Maryland
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
Clinical Trial Facility in Baltimore Maryland
Baltimore, Maryland
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
Clinical Trial Facility in Baltimore Maryland
Baltimore, Maryland
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
Clinical Trial Facility in Baltimore Maryland
Baltimore, Maryland
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
Clinical Trial Facility in Bangor Maine
Bangor, Maine 04402
?
mi
from
Bangor, ME
Click here to add this to my saved trials
Clinical Trial Facility in Banning California
Banning, California 92220
?
mi
from
Banning, CA
Click here to add this to my saved trials
Clinical Trial Facility in Baton Rouge Louisiana
Baton Rouge, Louisiana 70809
?
mi
from
Baton Rouge, LA
Click here to add this to my saved trials
Clinical Trial Facility in Bay Pines Florida
Bay Pines, Florida
?
mi
from
Bay Pines, FL
Click here to add this to my saved trials
Clinical Trial Facility in Belleville Illinois
Belleville, Illinois 62220
?
mi
from
Belleville, IL
Click here to add this to my saved trials
Clinical Trial Facility in Bend Oregon
Bend, Oregon
?
mi
from
Bend, OR
Click here to add this to my saved trials
Clinical Trial Facility in Beverly Hills California
Beverly Hills, California 90211
?
mi
from
Beverly Hills, CA
Click here to add this to my saved trials
Clinical Trial Facility in Biddeford Maine
Biddeford, Maine
?
mi
from
Biddeford, ME
Click here to add this to my saved trials
Clinical Trial Facility in Billerica Massachusetts
Billerica, Massachusetts 01821
?
mi
from
Billerica, MA
Click here to add this to my saved trials
Clinical Trial Facility in Billings Montana
Billings, Montana 59101
?
mi
from
Billings, MT
Click here to add this to my saved trials
Clinical Trial Facility in Billings Montana
Billings, Montana 59101
?
mi
from
Billings, MT
Click here to add this to my saved trials
Clinical Trial Facility in Birmingham Alabama
Birmingham, Alabama
?
mi
from
Birmingham, AL
Click here to add this to my saved trials
Clinical Trial Facility in Birmingham Alabama
Birmingham, Alabama
?
mi
from
Birmingham, AL
Click here to add this to my saved trials
Clinical Trial Facility in Boise Idaho
Boise, Idaho 83712
?
mi
from
Boise, ID
Click here to add this to my saved trials
Clinical Trial Facility in Boise Idaho
Boise, Idaho 83712
?
mi
from
Boise, ID
Click here to add this to my saved trials
Clinical Trial Facility in Boynton Beach Florida
Boynton Beach, Florida 33472
?
mi
from
Boynton Beach, FL
Click here to add this to my saved trials
Clinical Trial Facility in Bradenton Florida
Bradenton, Florida 34205
?
mi
from
Bradenton, FL
Click here to add this to my saved trials
Clinical Trial Facility in Bridgeport Connecticut
Bridgeport, Connecticut
?
mi
from
Bridgeport, CT
Click here to add this to my saved trials
Clinical Trial Facility in Buffalo New York
Buffalo, New York
?
mi
from
Buffalo, NY
Click here to add this to my saved trials
Clinical Trial Facility in Buffalo New York
Buffalo, New York
?
mi
from
Buffalo, NY
Click here to add this to my saved trials
Clinical Trial Facility in Burke Virginia
Burke, Virginia 22015
?
mi
from
Burke, VA
Click here to add this to my saved trials
Clinical Trial Facility in Calabash North Carolina
Calabash, North Carolina 28467
?
mi
from
Calabash, NC
Click here to add this to my saved trials
Clinical Trial Facility in Camp Hill Pennsylvania
Camp Hill, Pennsylvania 17011
?
mi
from
Camp Hill, PA
Click here to add this to my saved trials
Clinical Trial Facility in Canton Ohio
Canton, Ohio 44718
?
mi
from
Canton, OH
Click here to add this to my saved trials
Clinical Trial Facility in Cary North Carolina
Cary, North Carolina 27518
?
mi
from
Cary, NC
Click here to add this to my saved trials
Clinical Trial Facility in Chambersburg Pennsylvania
Chambersburg, Pennsylvania 17201
?
mi
from
Chambersburg, PA
Click here to add this to my saved trials
Clinical Trial Facility in Charleston South Carolina
Charleston, South Carolina 29412
?
mi
from
Charleston, SC
Click here to add this to my saved trials
Clinical Trial Facility in Charleston South Carolina
Charleston, South Carolina 29412
?
mi
from
Charleston, SC
Click here to add this to my saved trials
Clinical Trial Facility in Charlotte North Carolina
Charlotte, North Carolina 28207
?
mi
from
Charlotte, NC
Click here to add this to my saved trials
Clinical Trial Facility in Charlotte North Carolina
Charlotte, North Carolina 28207
?
mi
from
Charlotte, NC
Click here to add this to my saved trials
Clinical Trial Facility in Charlotte Hall Maryland
Charlotte Hall, Maryland 20622
?
mi
from
Charlotte Hall, MD
Click here to add this to my saved trials
Clinical Trial Facility in Chicago Illinois
Chicago, Illinois
?
mi
from
Chicago, IL
Click here to add this to my saved trials
Clinical Trial Facility in Cincinnati Ohio
Cincinnati, Ohio
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
Clinical Trial Facility in Cincinnati Ohio
Cincinnati, Ohio
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
Clinical Trial Facility in Clearwater Florida
Clearwater, Florida 33756
?
mi
from
Clearwater, FL
Click here to add this to my saved trials
Clinical Trial Facility in Cleveland Ohio
Cleveland, Ohio
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
Clinical Trial Facility in Coeur D'Alene Idaho
Coeur D'Alene, Idaho 83814
?
mi
from
Coeur D'Alene, ID
Click here to add this to my saved trials
Clinical Trial Facility in Colorado Springs Colorado
Colorado Springs, Colorado 80910
?
mi
from
Colorado Springs, CO
Click here to add this to my saved trials
Clinical Trial Facility in Colorado Springs Colorado
Colorado Springs, Colorado 80910
?
mi
from
Colorado Springs, CO
Click here to add this to my saved trials
Clinical Trial Facility in Columbia Maryland
Columbia, Maryland 21044
?
mi
from
Columbia, MD
Click here to add this to my saved trials
Clinical Trial Facility in Columbia Maryland
Columbia, Maryland 21044
?
mi
from
Columbia, MD
Click here to add this to my saved trials
Clinical Trial Facility in Columbia Missouri
Columbia, Missouri 65201
?
mi
from
Columbia, MO
Click here to add this to my saved trials
Clinical Trial Facility in Columbia South Carolina
Columbia, South Carolina
?
mi
from
Columbia, SC
Click here to add this to my saved trials
Clinical Trial Facility in Columbus Ohio
Columbus, Ohio 43214
?
mi
from
Columbus, OH
Click here to add this to my saved trials
Clinical Trial Facility in Columbus Ohio
Columbus, Ohio 43214
?
mi
from
Columbus, OH
Click here to add this to my saved trials
Clinical Trial Facility in Cortlandt Manor New York
Cortlandt Manor, New York 10567
?
mi
from
Cortlandt Manor, NY
Click here to add this to my saved trials
Clinical Trial Facility in Covington Louisiana
Covington, Louisiana 70433
?
mi
from
Covington, LA
Click here to add this to my saved trials
Clinical Trial Facility in Cranston Rhode Island
Cranston, Rhode Island 02920
?
mi
from
Cranston, RI
Click here to add this to my saved trials
Clinical Trial Facility in Crystal River Florida
Crystal River, Florida 34429
?
mi
from
Crystal River, FL
Click here to add this to my saved trials
Clinical Trial Facility in Cumberland Rhode Island
Cumberland, Rhode Island 02864
?
mi
from
Cumberland, RI
Click here to add this to my saved trials
Clinical Trial Facility in Dallas Texas
Dallas, Texas 75390
?
mi
from
Dallas, TX
Click here to add this to my saved trials
Clinical Trial Facility in Danville Virginia
Danville, Virginia 24541
?
mi
from
Danville, VA
Click here to add this to my saved trials
Clinical Trial Facility in Dayton Ohio
Dayton, Ohio 45409
?
mi
from
Dayton, OH
Click here to add this to my saved trials
Clinical Trial Facility in Daytona Beach Florida
Daytona Beach, Florida 32117
?
mi
from
Daytona Beach, FL
Click here to add this to my saved trials
Clinical Trial Facility in Dearborn Michigan
Dearborn, Michigan 48124
?
mi
from
Dearborn, MI
Click here to add this to my saved trials
Clinical Trial Facility in Deerfield Beach Florida
Deerfield Beach, Florida 33442
?
mi
from
Deerfield Beach, FL
Click here to add this to my saved trials
Clinical Trial Facility in Delray Beach Florida
Delray Beach, Florida 33406
?
mi
from
Delray Beach, FL
Click here to add this to my saved trials
Clinical Trial Facility in Denver Colorado
Denver, Colorado
?
mi
from
Denver, CO
Click here to add this to my saved trials
Clinical Trial Facility in Des Moines Iowa
Des Moines, Iowa
?
mi
from
Des Moines, IA
Click here to add this to my saved trials
Clinical Trial Facility in Dunwoody Georgia
Dunwoody, Georgia 30338
?
mi
from
Dunwoody, GA
Click here to add this to my saved trials
Clinical Trial Facility in Durham North Carolina
Durham, North Carolina
?
mi
from
Durham, NC
Click here to add this to my saved trials
Clinical Trial Facility in East Point Georgia
East Point, Georgia
?
mi
from
East Point, GA
Click here to add this to my saved trials
Clinical Trial Facility in Eatonton Georgia
Eatonton, Georgia 31024
?
mi
from
Eatonton, GA
Click here to add this to my saved trials
Clinical Trial Facility in Edgewater Florida
Edgewater, Florida
?
mi
from
Edgewater, FL
Click here to add this to my saved trials
Clinical Trial Facility in Elizabeth New Jersey
Elizabeth, New Jersey 07202
?
mi
from
Elizabeth, NJ
Click here to add this to my saved trials
Clinical Trial Facility in Elyria Ohio
Elyria, Ohio
?
mi
from
Elyria, OH
Click here to add this to my saved trials
Clinical Trial Facility in Encino California
Encino, California 91436
?
mi
from
Encino, CA
Click here to add this to my saved trials
Clinical Trial Facility in Escondido California
Escondido, California 92025
?
mi
from
Escondido, CA
Click here to add this to my saved trials
Clinical Trial Facility in Evansville Indiana
Evansville, Indiana 47713
?
mi
from
Evansville, IN
Click here to add this to my saved trials
Clinical Trial Facility in Fall River Massachusetts
Fall River, Massachusetts 02720
?
mi
from
Fall River, MA
Click here to add this to my saved trials
Clinical Trial Facility in Falls Church Virginia
Falls Church, Virginia 22042
?
mi
from
Falls Church, VA
Click here to add this to my saved trials
Clinical Trial Facility in Fargo North Dakota
Fargo, North Dakota 58122
?
mi
from
Fargo, ND
Click here to add this to my saved trials