The Effect of Platelet Rich Plasma (PRP) on Post Operative Pain in Anterior Cruciate Ligament Reconstruction
| Status: | Recruiting |
|---|---|
| Conditions: | Post-Surgical Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 16 - Any |
| Updated: | 4/21/2016 |
| Start Date: | December 2012 |
| End Date: | December 2016 |
"Effect of Intraoperative Application of Autologous PRP on Post Operative Morbidity in ACL Reconstruction Using Autologous Bone Patellar Tendon Bone Graft Harvest"
The purpose of this research study is to investigate whether or not platelet rich plasma
(PRP) may help to improve tendon healing and decrease post operative pain in patients
undergoing anterior cruciate ligament (ACL) reconstructive surgery using their own patellar
tendons as autografts.
(PRP) may help to improve tendon healing and decrease post operative pain in patients
undergoing anterior cruciate ligament (ACL) reconstructive surgery using their own patellar
tendons as autografts.
There is currently a paucity of well-designed, prospective, randomized, blinded (Level 1)
clinical studies that carefully and comprehensively investigate the role of PRP in ACL
surgery. Specifically, ACL reconstruction using Bone Patellar Tendon Bone (BPTB) harvest and
the role of PRP in decreasing postoperative pain at the donor site. Given the need for a
highly powered study to demonstrate the clinical efficacy of PRP in ACL reconstruction, the
investigators have designed a prospective, randomized, level 1, double-blinded study to
evaluate the effects of PRP on the specific outcomes of donor site pain and radiographic
measures of graft healing and incorporation.
The aim of this study is to evaluate the efficacy of intra-operatively applied autologous
PRP in reducing donor site morbidity and increasing radiographic healing in ACL
reconstruction using autologous BPTB.
clinical studies that carefully and comprehensively investigate the role of PRP in ACL
surgery. Specifically, ACL reconstruction using Bone Patellar Tendon Bone (BPTB) harvest and
the role of PRP in decreasing postoperative pain at the donor site. Given the need for a
highly powered study to demonstrate the clinical efficacy of PRP in ACL reconstruction, the
investigators have designed a prospective, randomized, level 1, double-blinded study to
evaluate the effects of PRP on the specific outcomes of donor site pain and radiographic
measures of graft healing and incorporation.
The aim of this study is to evaluate the efficacy of intra-operatively applied autologous
PRP in reducing donor site morbidity and increasing radiographic healing in ACL
reconstruction using autologous BPTB.
Inclusion Criteria:
- Primary ACL Reconstruction
- Outerbridge
- Minimum follow up of two years
- No ligamentous secondary injury
- Willingness to participate in study
Exclusion Criteria:
- Any previous knee injury
- prior history of anterior knee pain
- Outerbridge classification 3 or greater
- Revision ACL
- Diabetic or smoker
- Workers compensation patient
- pregnant or nursing women
- Any patient with limited English Proficiency
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