Gene Changes and Risk Factors in Nuclear Workers in Mayak, Russia
| Status: | Archived |
|---|---|
| Conditions: | Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
Germline Genetic Variation and Risk of Chromosome Aberrations Among Mayak Nuclear Workers
RATIONALE: Collecting and studying samples of blood from workers exposed to high doses of
radiation may help the study of cancer in the future.
PURPOSE: This clinical trial is studying gene changes and risk factors in nuclear workers in
Mayak, Russia.
OBJECTIVES:
- Assess genetic polymorphism contribution in stable chromosome aberration frequency in
nuclear workers in Mayak, Russia exposed to high-doses of radiation.
OUTLINE: This is a multicenter study.
Blood samples are collected annually during routine medical exams to assess intermediate
biomarkers of radiation exposure. Samples are analyzed by mBAND biodosimetry and mFISH to
measure intrachromosomal aberrations. Germline genetic variation in DNA repair and other
genes is also assessed as a risk factor for chromosomal aberration frequency.
Participants complete a short questionnaire assessing their jobs, as well as history of
family health, smoking and alcohol consumption, and benign tumors, if any. Additional
information is obtained from participants' medical records.
We found this trial at
2
sites
National Cancer Institute (NCI) The National Cancer Institute (NCI) is part of the National Institutes...
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Columbia Presbyterian Med Ctr On January 1, 1998, The New York Hospital publicly announced its...
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