A Study to Evaluate the Pharmacokinetics of PCI-32765 in Participants With Varying Degrees of Hepatic Impairment

This is an open-label (all people know the identity of the intervention), single-dose,
multi-center (study conducted at multiple sites), non-randomized study to access the
pharmacokinetics of PCI-32765 in participants who either have mild, moderate, or severe
hepatic impairment or qualify for the control group (normal liver function). The study
mainly consists of 3 phases: screening phase (within 21 days prior to the first dose of
study medication), treatment phase, and a follow up phase (10 to 12 days after the last dose
of study medication). In the treatment phase, participants will receive single oral dose of
PCI-32765 on Day 1. Liver impairment will be classified according to the Child-Pugh
Classification of Severity of Liver Disease, as: normal, mild, moderate, and severe. Total
30 participants (24 with hepatic impairment [6 mild, 9 moderate and 9 severe] at baseline
and 6 in the control group according to Child-Pugh criteria) will be enrolled. Participants
in the control group will be enrolled after the participants with mild or moderate hepatic
impairment have completed the study. Safety evaluations for adverse events, clinical
laboratory tests, electrocardiogram, vital signs, and physical examination will be monitored
throughout the study. The total duration of study for each participant will be approximately
for 29 to 33 days.

Inclusion Criteria:

- Stable hepatic function as confirmed by the serum bilirubin and transaminase levels
measured during screening and those measured within 48 hours prior to PCI-32765
administration

- Must be hepatically impaired as defined by the Child-Pugh classification of severity
of liver disease

- Control group must have good health with normal liver function

- Participants with controlled hypertension and those with problems directly associated
with the primary diagnosis of hepatic impairment

- Concomitant medications to treat underlying disease states or medical conditions
related to hepatic impairment are allowed

- Agrees to protocol-defined use of effective contraception

Exclusion Criteria:

- Clinically significant renal laboratory findings including serum creatinine more than
1.5 x the upper limit of normal (ULN) and/or calculated creatinine clearance of less
than 60 ml per minute per 1.73 square meter

- Clinically significant abnormal laboratory tests, physical examination, vital signs
or electrocardiogram at screening or at admission to the study center

- Antiviral therapy for active hepatitis infection at time of screening

- Use of any anti-coagulation therapy including vitamin K antagonists, low molecular
weight heparin, or other anticoagulants