A Drug-Drug Interaction Study of the Effect of Rabeprazole, Itraconazole or Fluconazole on the Pharmacokinetics of Vismodegib
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 8/3/2016 |
| Start Date: | February 2013 |
| End Date: | May 2013 |
A Clinical Drug-Drug Interaction Study to Evaluate the Effect of a Proton Pump Inhibitor, a Combined P-gp/CYP3A4 Inhibitor, and a CYP2C9 Inhibitor on the Pharmacokinetics of Vismodegib
This randomized, open-label, 4-arm, multiple-dose study will evaluate the effect of
coadministration of a protein pump inhibitor, an inhibitor of P-glycoprotein and CYP3A4, or
an inhibitor of CYP2C9 on the pharmacokinetics of vismodegib in healthy female subjects of
non-childbearing potential. Subjects will be randomized to receive multiple oral doses of
vismodegib, alone or in combination with multiple oral doses of either rabeprazole,
itraconazole or fluconazole. Anticipated time on study treatment is up to 11 days.
coadministration of a protein pump inhibitor, an inhibitor of P-glycoprotein and CYP3A4, or
an inhibitor of CYP2C9 on the pharmacokinetics of vismodegib in healthy female subjects of
non-childbearing potential. Subjects will be randomized to receive multiple oral doses of
vismodegib, alone or in combination with multiple oral doses of either rabeprazole,
itraconazole or fluconazole. Anticipated time on study treatment is up to 11 days.
Inclusion Criteria:
- Females of non-childbearing potential
- Body mass index (BMI) 18 to 32 kg/m2, inclusive
- In good health, determined by no clinically significant findings from medical
history, physical examination. 12-lead ECG, and vital signs
- Clinical laboratory evaluations, complete blood count and urinalysis within the
normal range for the test laboratory, unless not deemed clinically significant by the
investigator
- Negative test for drugs of abuse at screening and check-in (including alcohol)
- Negative for hepatitis B, hepatitis C and HIV infection
- Non-childbearing potential is defined as: non-pregnant, non-lactating, and either
postmenopausal for at least 1 year or surgically sterile (e.g. bilateral oophorectomy
and/or hysterectomy)
Exclusion Criteria:
- Significant history or clinical evidence of any metabolic (including type 1 or 2
diabetes). allergic, dermatological, hepatic, renal, hematological, pulmonary,
cardiovascular, endocrine, GI (including gastric or duodenal ulcers),
Zollinger-Ellison syndrome, Barrett's esophagus, urological, neurological, or
psychiatric disorder
- History of inflammatory arthritis
- History of symptomatic hypotension
- History of seizure disorders
- History of bipolar or major depressive disorder
- History of stomach or intestinal surgery or resection that would potentially alter
absorption and/or excretion of orally administered drugs (appendectomy, hernia
repair, and/or cholecystectomy will be allowed)
- History of alcoholism or drug addiction within 1 year prior to check-in
- Use of any tobacco- or nicotine-containing products within 6 months prior to check-in
- Participation in any other investigational study drug or biological agent trial in
which receipt of investigational study drug occurred within 5 half-lives or 30 days,
whichever is longer, prior to check-in
- Use of PPIs, H2-receptor antagonists, or antacids within 1 month prior to check-in
- History of chronic PPI use (> 30 days of continuous daily dosing) within 6 months of
check-in
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