The Effects of Anesthesia on Patients Undergoing Surgery for Repair of a Thoracoabdominal Aneurysm.
| Status: | Terminated |
|---|---|
| Conditions: | Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 21 - 100 |
| Updated: | 7/27/2016 |
| Start Date: | May 2012 |
| End Date: | February 2014 |
The Effect of Anesthesia on Potential CSF and Serum Markers of Alzheimer's Disease.
Alzheimer's disease represents a growing public health problem in developed countries.
Although the pathogenesis is not clearly defined, accumulation of extracellular amyloid,
neurofibrillary tangles and neuronal loss are the hallmarks of Alzheimer's disease. The
effect of anesthetic agents on changes in these proteins in humans is not well
characterized, but in-vitro evidence suggests that anesthetic agents can accelerate
potential pathogenic mechanisms, such as increasing amyloid formation or rates of apoptosis
in cultured cells and increasing amyloid levels in mice. Human data on the effect of
anesthetic agents on amyloid and tau proteins is limited to a small series of 11 patients
and showed a significant increase in tau levels after exposure to anesthetics. In this study
we propose to measure CSF and serum biomarkers in a population of patients with normal CSF
dynamics, who are undergoing surgery for repair of a thoracoabdominal aneurysm. We will also
obtain preliminary data on whether changes in CSF levels of these proteins are associated
with postoperative delirium or cognitive change.
Although the pathogenesis is not clearly defined, accumulation of extracellular amyloid,
neurofibrillary tangles and neuronal loss are the hallmarks of Alzheimer's disease. The
effect of anesthetic agents on changes in these proteins in humans is not well
characterized, but in-vitro evidence suggests that anesthetic agents can accelerate
potential pathogenic mechanisms, such as increasing amyloid formation or rates of apoptosis
in cultured cells and increasing amyloid levels in mice. Human data on the effect of
anesthetic agents on amyloid and tau proteins is limited to a small series of 11 patients
and showed a significant increase in tau levels after exposure to anesthetics. In this study
we propose to measure CSF and serum biomarkers in a population of patients with normal CSF
dynamics, who are undergoing surgery for repair of a thoracoabdominal aneurysm. We will also
obtain preliminary data on whether changes in CSF levels of these proteins are associated
with postoperative delirium or cognitive change.
Inclusion Criteria:
- age 21-100 years of age
- Patients presenting for surgical repair of a thoracoabdominal aneurysm
- Insertion of a CSF spinal drain for clinically indicated reason
Exclusion Criteria:
- Patients with pre-existing delirium
- Inability to speak and understand English
- Severe hearing impairment, resulting in inability to converse
- Pregnancy. Pregnancy status will be assessed using a serum pregnancy test during
preoperative evaluation as part of the standard of care.
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