Methylnaltrexone Use for Opioid-induced Postoperative Constipation
| Status: | Completed |
|---|---|
| Conditions: | Constipation |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 12 - 21 |
| Updated: | 10/14/2017 |
| Start Date: | May 2013 |
| End Date: | May 2015 |
The Use of Methylnaltrexone to Reduce Post-operative Opioid-induced Constipation in the Pediatric Spinal Fusion Patient
The purpose of this study is to determine whether the routine use of methylnaltrexone in the
post-operative pediatric spinal fusion patient will decrease the incidence of constipation.
post-operative pediatric spinal fusion patient will decrease the incidence of constipation.
Methylnaltrexone will be given to pediatric patients post-operative from spinal fusion
surgery on post-operative day number 3 and then again on postoperative day number 4, if no
laxation achieved. Various outcome measures, safety and efficacy of the drug will be observed
and recorded.
surgery on post-operative day number 3 and then again on postoperative day number 4, if no
laxation achieved. Various outcome measures, safety and efficacy of the drug will be observed
and recorded.
Inclusion Criteria:
- spinal fusion surgery
- current opioid use
- 12 years of age and older
- no or inadequate bowel movement by post-operative day 3
Exclusion Criteria:
- known or expected mechanical bowel obstruction
- known or suspected lesions of the GI tract
- unexpected transfer to ICU
- unexpected return to the operating room
- patient or parent refusal of methylnaltrexone
- incomplete data concerning time to laxation
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