ECHELON-2: A Comparison of Brentuximab Vedotin and CHP With Standard-of-care CHOP in the Treatment of Patients With CD30-positive Mature T-cell Lymphomas



Status:Active, not recruiting
Conditions:Lymphoma
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:10/13/2018
Start Date:January 2013
End Date:December 2019

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Trial Summary
Trial Overview
Inclusion Criteria

A Randomized, Double-blind, Placebo-controlled, Phase 3 Study of Brentuximab Vedotin and CHP (A+CHP) Versus CHOP in the Frontline Treatment of Patients With CD30-positive Mature T-cell Lymphomas

This is a double-blind, randomized, multicenter, phase 3 clinical trial to compare the
efficacy and safety of brentuximab vedotin in combination with CHP with the standard-of-care
CHOP in patients with CD30-positive mature T-cell lymphomas.


Inclusion Criteria:

- Patients with newly diagnosed, CD30-positive mature T-cell lymphomas

- Fluorodeoxyglucose (FDG)-avid disease by PET and measurable disease of at least 1.5 cm
by CT

- Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to 2

Exclusion Criteria:

- History of another primary invasive malignancy that has not been in remission for at
least 3 years

- Current diagnosis of primary cutaneous CD30-positive T-cell lymphoproliferative
disorders and lymphomas or mycosis fungoides

- History of progressive multifocal leukoencephalopathy (PML)

- Cerebral/meningeal disease related to the underlying malignancy
We found this trial at
33
sites
Memorial Sloan-Kettering Cancer Center at Commack
650 Commack Rd
Commack, New York 11725
(631) 623-4000
Principal Investigator: Steven Horwitz, MD
Phone: 631-623-4000
Memorial Sloan-Kettering Cancer Center at Commack Memorial Sloan Kettering Cancer Center - the world's oldest...
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Commack, NY
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Beth Israel Deaconess Medical Center
330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
Principal Investigator: Eric Jacobsen, MD
Phone: 617-667-1958
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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Boston, MA
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Montefiore Medical Center
3550 Jerome Avenue
Bronx, New York 10467
(718) 920-4321
Principal Investigator: Ramakrishna Battini, MD
Phone: 718-920-6642
Montefiore Medical Center As the academic medical center and University Hospital for Albert Einstein College...
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Bronx, NY
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Holden Comprehensive Cancer Center at University of Iowa
200 Hawkins Drive
Iowa City, Iowa 52242
800-237-1225
Principal Investigator: Brian Link, MD
Phone: 319-467-5827
Holden Comprehensive Cancer Center at University of Iowa Holden Comprehensive Cancer Center is dedicated to...
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Iowa City, IA
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Orlando Health
24 Sturtevant St
Orlando, Florida 32806
Principal Investigator: Jose Sarriera, MD
Phone: 321-841-7022
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Orlando, FL
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James P. Wilmot Cancer Center at University of Rochester Medical Center
601 Elmwood Avenue
Rochester, New York 14642
(585) 275-5830
Principal Investigator: Jonathan Friedberg, MD
Phone: 585-275-5825
James P. Wilmot Cancer Center at University of Rochester Medical Center The Wilmot Cancer Center...
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Rochester, NY
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Royal Adelaide Hospital
Adelaide,
Principal Investigator: Ian Lewis, MD
Phone: 866-333-7436
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Adelaide,
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Memorial Sloan-Kettering Cancer Center - Basking Ridge
136 Mountainview Blvd
Basking Ridge, New Jersey 7920
(908) 542-3000
Principal Investigator: Steven Horwitz
Phone: 908-542-3000
Memorial Sloan-Kettering Cancer Center - Basking Ridge At Memorial Sloan Kettering Basking Ridge, we offer...
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Dana-Farber Cancer Institute
450 Brookline Ave
Boston, Massachusetts 2215
617-632-3000
Principal Investigator: Eric Jacobsen, MD
Phone: 617-632-2324
Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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Boston, MA
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Albert Einstein Cancer Center
Bronx, New York 10461
Principal Investigator: Ramakrishna Battini, MD
Phone: 718-405-8545
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Bronx, NY
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University of Virginia
Charlottesville, Virginia 22903
(434) 924-0311
Principal Investigator: Michael Douvas, MD
Phone: 434-982-3947
University of Virginia The University of Virginia is distinctive among institutions of higher education. Founded...
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University of Illinois at Chicago
2035 W Taylor St
Chicago, Illinois
(312) 996-4350
Principal Investigator: David Peace
Phone: 312-413-1906
University of Illinois at Chicago A major research university in the heart of one of...
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Jewish Hospital, The
Cincinnati, Ohio 45236
Principal Investigator: Miguel Islas-Ohlmayer, MD
Phone: 513-751-2273
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Cincinnati, OH
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Cleveland Clinic, The
Cleveland, Ohio 44195
Principal Investigator: Deepa Jagadeesh, MD
Phone: 216-445-9451
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Cleveland, OH
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Charles A. Sammons Cancer Center at Baylor University Medical Center
Dallas, Texas 75246
Principal Investigator: Estil Vance, MD
Phone: 214-818-8325
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Dallas, TX
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City of Hope National Medical Center
1500 East Duarte Road
Duarte, California 91010
626-256-HOPE (4673)
Principal Investigator: Jasmine Zain
Phone: 626-218-0697
City of Hope National Medical Center City of Hope is dedicated to making a difference...
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Shands Cancer Center / University of Florida
Gainesville, Florida 32610
Principal Investigator: Nam Dang, MD
Phone: 352-265-0680
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Banner MD Anderson Cancer Center
Gilbert, Arizona 85234
Principal Investigator: Javier Munoz
Phone: 480-256-3116
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Gilbert, AZ
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Hackensack University Medical Center
30 Prospect Ave
Hackensack, New Jersey 07601
(201) 996-2000
Principal Investigator: Tatyana Feldman, MD
Phone: 551-996-3277
Hackensack University Medical Center Hackensack University Medical Center, part of the Hackensack University Health Network,...
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M.D. Anderson Cancer Center at University of Texas
Houston, Texas 77030
Principal Investigator: Michelle Fanale, MD
Phone: 713-792-0311
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Houston, TX
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Cardinal Bernardin Cancer Center at Loyola University Medical Center
2160 S. First Ave.
Maywood, Illinois 60153
888-584-7888
Principal Investigator: Scott Smith, MD
Phone: 708-327-3228
Cardinal Bernardin Cancer Center at Loyola University Medical Center The Cardinal Bernardin Cancer Center is...
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Maywood, IL
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Sarah Cannon Research Institute
3322 West End Avenue
Nashville, Tennessee 37203
(615)329-SCRI (7274)
Principal Investigator: Ian Flinn, MD
Phone: 615-329-7274
Sarah Cannon Research Institute Sarah Cannon Research Institute (SCRI) is a global strategic research organization...
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Nashville, TN
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Weill-Cornell Medical College
New York, New York 10021
Principal Investigator: Jia Ruan, MD
Phone: 212-746-1858
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New York, NY
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Memorial Sloan Kettering Cancer Center
1275 York Ave
New York, New York 10021
(212) 639-2000
Principal Investigator: Steven Horwitz, MD
Phone: 212-639-2696
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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Columbia University Medical Center
630 W 168th St
New York, New York
212-305-2862
Principal Investigator: Owen O'Connor, MD
Phone: 212-326-5732
Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
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Mercy Clinic Oncology
Oklahoma City, Oklahoma 73120
Principal Investigator: Christopher Thompson, MD
Phone: 405-752-3402
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Oklahoma City, OK
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Thomas Jefferson University
1020 Walnut St
Philadelphia, Pennsylvania 19107
(215) 955-6000
Principal Investigator: Seyfettin Onder-Alpdogan, MD
Phone: 215-955-5769
Thomas Jefferson University We are dedicated to the health sciences and committed to educating professionals,...
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VCU Medical Center
1250 E. Marshall St.
Richmond, Virginia 23298
(804) 828-9000
Principal Investigator: John McCarty, MD
Phone: 804-828-4596
Virginia Commonwealth University Medical Center The Virginia Commonwealth University Health System is an urban, comprehensive...
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Richmond, VA
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Washington University School of Medicine
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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Saint Louis, MO
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Benaroya Research Institute at Virginia Mason Medical Center
Seattle, Washington 98101
Principal Investigator: David Aboulafia, MD
Phone: 206-342-6500
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Seattle Cancer Care Alliance / University of Washington
Seattle, Washington 98109
Principal Investigator: Andrei Shustov, MD
Phone: 206-288-6747
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Stanford Cancer Center
Stanford, California 94305
Principal Investigator: Ranjana Advani, MD
Phone: 650-736-2563
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Stanford, CA
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University of Kansas Cancer Center
Westwood, Kansas 66205
Principal Investigator: Abdulraheem Yacoub, MD
Phone: 913-588-4787
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