Effect of Steroids on Thrombosis (Blood Clot Formation) and Inflammation in Patients Undergoing Hip Surgery
| Status: | Completed |
|---|---|
| Conditions: | Orthopedic |
| Therapuetic Areas: | Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 50 - 90 |
| Updated: | 4/2/2016 |
| Start Date: | October 2012 |
| End Date: | June 2014 |
| Contact: | Kethy Jules-Elysee, MD |
| Email: | JulesElyseeK@hss.edu |
| Phone: | 212-606-1206 |
Effect of Steroids Given Over 24 Hours on Cytokine Release, Urinary Desmosine Level and Thrombogenic Markers in Patients Undergoing Unilateral Total Hip Replacement
Studies have shown that surgery causes some reactions in your body consistent with
inflammation. When the inflammation is extensive, it may affect different parts of the body
including the lungs. Corticosteroids are commonly used to treat inflammation and are
different from performance enhancing steroids associated with athletics. The purpose of this
study is to determine the influence of low dose steroids given 3 times in a 24 hour period
on thrombotic markers (markers that are associated with increased risks of clotting, a
possible complication of surgery), IL-6 cytokine release (part of the stress response seen
with surgery), and urine desmosine levels (a marker of lung injury) in a randomized placebo
controlled trial patients undergoing total hip replacement.
inflammation. When the inflammation is extensive, it may affect different parts of the body
including the lungs. Corticosteroids are commonly used to treat inflammation and are
different from performance enhancing steroids associated with athletics. The purpose of this
study is to determine the influence of low dose steroids given 3 times in a 24 hour period
on thrombotic markers (markers that are associated with increased risks of clotting, a
possible complication of surgery), IL-6 cytokine release (part of the stress response seen
with surgery), and urine desmosine levels (a marker of lung injury) in a randomized placebo
controlled trial patients undergoing total hip replacement.
Inclusion Criteria:
- Patients undergoing unilateral total hip replacement with Drs. Douglas Padgett,
Thomas Sculco, or Edwin Su.
- Patients between the age of 50 and 90
Exclusion Criteria:
- Patients on steroid therapy regardless of dose or duration of treatment or those
requiring stress-dose steroids preoperatively
- Patients who are smokers
- Patients who have diabetes
- Patients who are <50 and >90 years of age
- Patients with history of prior difficulties tolerating corticosteroids
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Hospital for Special Surgery Founded in 1863, Hospital for Special Surgery is the nation
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