A Study of Odanacatib When Administered to Adolescents and Young Adults Treated With Glucocorticoids (MK-0822-066)

Inclusion Criteria:

- Female subjects of reproductive potential (or other female subjects at the discretion
of the investigator) must have negative serum pregnancy test and agree to use (and/or
have their partner use) two (2) acceptable methods of birth control beginning at the
prestudy visit throughout the study and until 2 weeks after the dose of study

- Receiving glucocorticoid therapy at a dose anticipated to be stable over the course
of the study period

- X-ray evidence of closed epiphyses (growth plate) at the hand

- Nonsmoker

Exclusion Criteria:

- Pregnant or unwilling to undergo pregnancy test

- History of stroke, chronic seizures, or major neurological disorder

- History of malignant neoplastic disease (cancer)

- Breastfeeding

- Primary growth disorder

- Any disease affecting the stomach or proximal small intestine resulting in
malabsorption

- Received treatment which might have influenced bone turnover, including anabolic
steroids, testosterone, calcitonin, calcitriol, alfacalcidol, excess vitamin A or
excess vitamin D, or cyclosporine or initiation of use of birth control pills
(estrogen-progestin combinations or progestin only, or depo provera) or other
estrogen containing medications, or thyroid hormone unless on a stable dose for at
least 1 month and has a normally functioning thyroid gland

- Previous treatment with any marketed or experimental bisphosphonate within 12 months

- History of, or evidence for, any clinically relevant metabolic bone disease (other
than glucocorticoid-induced bone loss) including but not limited to primary
hyperparathyroidism, hypoparathyroidism, hyperthyroidism, osteomalacia, and
osteogenesis imperfecta within previous 3 years

- History of hypothyroidism

- Consumes excessive amounts of alcohol, defined as greater than 3 glasses of alcoholic
beverages (1 glass is approximately equivalent to: beer [284 mL/10 ounces], wine [125
mL/4 ounces], or distilled spirits [25 mL/1 ounce]) per day

- Consumes excessive amounts, defined as greater than 6 servings (1 serving is
approximately equivalent to 120 mg of caffeine) of coffee, tea, cola, or other
caffeinated beverages per day

- Has had major surgery, donated or lost 1 unit of blood (approximately 500 mL), or
participated in another investigational study within 4 weeks

- History of significant multiple and/or severe allergies (including latex allergy), or
has had an anaphylactic reaction or significant intolerability to prescription or
non-prescription drugs or food

- Regular user (including "recreational use") of any illicit drugs, or has a history of
drug or alcohol abuse

- Unable to swallow tablets