BRAF/MEK/EGFR Inhibitor Combination Study in Colorectal Cancer (CRC)

This is an open-label, four-part Phase I/II study to investigate the safety,
pharmacokinetics, pharmacodynamics and clinical activity of trametinib (GSK1120212) and
dabrafenib (GSK2118436) when administered in combination with the anti-EGFR antibody
panitumumab in subjects with BRAF-mutation V600E positive colorectal cancer (CRC) and in
subjects with CRC with secondary resistance to prior anti-EGFR therapy. Part 1 of the study
will consist of dose-escalation cohorts, following a 3 + 3 enrollment scheme. Part 2 of the
study will consist of expansion cohorts to investigate safety and clinical activity of
dabrafenib in combination with panitumumab and trametinib plus dabrafenib in combination with
panitumumab. Part 3 of the study will be a randomized Phase II study comparing dosing with
dabrafenib in combination with panitumumab and trametinib plus dabrafenib in combination with
panitumumab as compared to the chemotherapy comparator (a regimen of FOLFOX, FOLFIRI or
irinotecan with or without panitumumab or bevacizumab). Subjects will be assigned to
treatment groups in a randomized fashion to compare safety and clinical activity. Part 4 of
the study will investigate the trametinib/panitumumab combination, including dose escalation
and subsequent cohort expansion in two patient populations: 1) BRAF-mutation V600E positive
CRC and 2) subjects with CRC who developed secondary resistance to prior anti-EGFR therapy.
The objective of Part 4 is to identify the recommended Phase 2 dose/regimen for trametinib
dosed in combination with panitumumab in dose escalation and to identify an initial signal of
clinical activity in expansion cohorts.

Inclusion Criteria: Subjects eligible for enrolment in this study must meet all of the
following criteria

- Provided written informed consent,

- Male or female >=18 years of age and able to swallow and retain orally administered
study treatment and does not have any clinically significant gastrointestinal (GI)
abnormalities that may alter absorption such as malabsorption syndrome or major
resection of the stomach and/or bowels.

- Part 1 and Part 2: Histologically- or cytologically-confirmed diagnosis of advanced or
metastatic BRAF V600E mutation positive CRC

- Part 4A and 4B ONLY: Histologically- or cytologically-confirmed diagnosis of advanced
or metastatic CRC that either harbours the BRAF V600E -mutation, as determined by
relevant genetic testing OR has developed secondary resistance to anti-EGFR therapy,
defined as patients that derived benefit (disease control based on investigator
assessment for >6 months OR partial response [confirmed or unconfirmed] based on
RECIST 1.1) from prior anti-EGFR-containing therapy (as defined below) and then
subsequently progressed on therapy. The anti-EGFR therapy must have been the most
recent therapy and the patient must have progressed based on investigator assessment
within 3 months of screening. Acceptable prior anti-EGFR-containing therapies include:
a. Monotherapy anti-EGFR, including cetuximab or panitumumab OR b.
irinotecan/anti-EGFR combo after previously having disease progression (based on
investigator assessment) on an irinotecan-containing regimen

- Part 3: Histologically- or cytologically-confirmed diagnosis of BRAFV600E mutation
positive advanced or metastatic colorectal cancer (CRC who are eligible to receive
fluoropyrimidine-containing chemotherapy regimen that have experienced documented
radiographic progression on one prior line of fluoropyrimidine-containing chemotherapy
(previous anti-EGFR therapy is excluded), Second-line for advanced/metastatic disease,
having failed or been intolerant to at least one regimen of
fluoropyrimidine-containing chemotherapy including irinotecan or oxaliplatin in the
advanced/metastatic setting. Enrollment in Part 3 may only occur following
confirmation of KRAS wild-type cancer.

- Archival tissue is required; if archival tissue is not available or found to not
contain tumor tissue, a fresh biopsy is required.

- Measurable disease per RECIST version 1.1.

- Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1.

- Men with a female partner of childbearing potential must have either had a prior
vasectomy or agree to use one of the contraception methods listed in protocol.

- Female subjects are eligible if: Non-childbearing potential defined as pre-menopausal
females with a documented tubal ligation or hysterectomy; or post-menopausal female
defined as 12 months of spontaneous amenorrhea to be verified with a
follicle-stimulating hormone (FSH) level >40 Milli-international units per milliliter
(MIU/mL) and estradiol level <40 picogram per milliliter (pg/mL). Child-bearing
potential and agrees to use one of the contraceptive methods listed in protocol.

- Female subjects must agree to use contraception from 7 days prior to the first dose of
study drug(s) until 6 months after the last dose of panitumumab, until 4 months after
the last dose of trametinib, or 4 weeks after the last dose of dabrafenib, whichever
is longer. Additionally, women of childbearing potential must have had a negative
serum pregnancy test within 7 days prior to the first dose of study drug(s).

- Adequate organ system function as defined in absolute neutrophil count greater than or
equal to 1.2X10^9/Liter (L), hemoglobin greater than or equal to 9 grams per deciliter
(g/dL) or 5.6 millimoles per litre (mmol/L), platelets greater than or equal to 75 ×
10^9/L, Prothrombin Time / International Normalized Ratio (PT/INR) and Partial
Thromboplastin Time (PTT) less than or equal to 1.5X upper limit of normal (ULN);
serum magnesium greater than or equal to the lower limit of normal (LLN); albumin
greater than or equal to 2.5 g/dL or 25 grams per liter (g/L), total bilirubin less
than or equal to 1.5XULN, and Aspartate aminotransferase (AST) and Alanine
aminotransferase (ALT) less than or equal to 2.5X ULN; creatinine less than or equal
to 1.5XULN or calculated creatinine clearance greater than or equal to 50mL/min; left
ventricular ejection fraction (LVEF) greater than or equal to the LLN by
echocardiography (ECHO) or multigated acquisition scan (MUGA).

- Subjects enrolled in France or Italy: In France or Italy, a subject will be eligible
for inclusion in this study only if either affiliated to, or a beneficiary of, a
social security category.

Exclusion Criteria: Subjects meeting any of the following criteria must not be enrolled in
the study

- History of prior malignancy, other than colorectal cancer.

- Any serious and/or unstable pre-existing medical, psychiatric disorder or other
conditions that could interfere with subject's safety, obtaining informed consent or
compliance to the study procedures.

- Current active liver or biliary disease (with the exception of Gilbert's syndrome or
asymptomatic gallstones, liver metastases or otherwise stable chronic liver disease
per investigator's assessment).

- History of sensitivity to heparin or heparin-induced thrombocytopenia.

- Currently receiving cancer therapy (chemotherapy, radiation therapy, immunotherapy or
biologic therapy).

- Prior exposure to a MEK inhibitor.

- Part 1, Part 2 and BRAF-mutant patients in Part 4 ONLY: Prior exposure to a BRAF
inhibitor.

- Part 1, Part 2 and BRAF-mutant patients in Part 4 ONLY: Known presence of
KRAS-mutation based on previous KRAS-testing. Note: Propsective KRAS testing is not
required. However, if the results of previous KRAS testing are known, they must be
used in assessing eligibility. KRAS testing will be performed retrospectively for all
patients.

- Part 3: Prior exposure to EGFR inhibitors or an anti-EGFR antibody

- Received an investigational or approved anti-cancer drug within 4 weeks, or within 5
half-lives (whichever is shorter) of the first dose of study drug(s). At least 14 days
must have passed between the last dose of prior investigational agent and the first
dose of study drug(s).

- Part 3: Received more than one prior anti-cancer therapy in the metastatic setting,
exclusive of previous adjuvant regimens. Previous investigational anti-cancer therapy
in the metastatic setting is prohibited.

- Current use of a prohibited medication or requirement to dose with any of these
medications during treatment with study drug(s).

- Known Hepatitis B, or Hepatitis C infection.

- Any major surgery, radiotherapy or immunotherapy within the 4 weeks prior to first
dose of study drug(s). Limited radiotherapy with in the 2 weeks prior to first dose of
study drug(s).

- Chemotherapy regimens with delayed toxicity within the 3 weeks prior to first dose of
study drug(s). Chemotherapy regimens given continuously or on a weekly basis with
limited potential for delayed toxicity within 2 weeks prior to first dose of study
drug(s).

- Unresolved toxicity greater than National Cancer Institute Common Terminology Criteria
for Adverse Events (NCI-CTCAE) version 4 Grade 1 from previous anti-cancer therapy,
with the exception of Grade 2 alopecia, Grade 2 neuropathy, or laboratory values that
are allowed per inclusion criteria.

- History of retinal vein occlusion (RVO).

- Presence of active gastrointestinal disease or other condition that will interfere
significantly with the absorption, distribution, metabolism or excretion of drugs.
Previous colectomy is acceptable.

- Subjects with brain metastases are excluded, unless: All known lesions must be
previously treated with surgery or stereotactic radio-surgery, and Brain lesion(s), if
present, must be confirmed stable (i.e., no increase in lesion size) for >=90 days
prior to first dose of study drug(s). This must be documented with two consecutive MRI
or CT scans using contrast, and Asymptomatic with no corticosteroids requirement for
>=30 days prior to first dose of study drug(s), and No enzyme-inducing anticonvulsants
for >=14 days prior to first dose of study drug(s). In addition, for subjects that had
brain metastases but currently have no evidence of disease (NED), NED for >=12 weeks
is required and must be confirmed by two consecutive MRI or CT scans (using contrast)
separated by >=6 weeks, prior to randomization. Enrollment of a subject with brain
metastases who meet the above criteria requires approval of a GlaxoSmithKline (GSK)
Medical Monitor.

- Psychological, familial, sociological or geographical conditions that do not permit
compliance with the protocol.

- History or evidence of cardiovascular risk including any of the following: LVEF QT interval corrected for heart rate using the Bazett's formula (QTcB;) ≥ 480
milliseconds (msec);.History or evidence of current clinically significant
uncontrolled arrhythmias. Exception: Subjects with controlled atrial fibrillation for
>30 days prior to randomization are eligible. History of acute coronary syndromes
(including myocardial infarction and unstable angina), coronary angioplasty, or
stenting within 6 months prior to randomization. History or evidence of current >=
Class II congestive heart failure as defined by New York Heart Association (NYHA).
Treatment refractory hypertension defined as a blood pressure of systolic> 140
millimeter of mercury (mm Hg) and/or diastolic > 90 mm Hg which cannot be controlled
by anti-hypertensive therapy; Subjects with intra-cardiac defibrillators or permanent
pacemakers; Known cardiac metastases

- Unstable pulmonary embolism, deep vein thrombosis, or other significant
arterial/venous thromboembolic event <=30 days before randomization. If on
anticoagulation, subject must be on stable therapeutic dose prior to randomization.

- Subjects with a history of pneumonitis or interstitial lung disease (ILD).

- Known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs
chemically related to the study drug(s) or their excipients.

- Pregnant or lactating female.

- Unwillingness or inability to follow the procedures outlined in the protocol.

- Uncontrolled diabetes or other medical condition that may interfere with assessment of
toxicity.