Safety, Pharmacokinetic, and Pharmacodynamic Study of NKTT120 in Adult Patients With Stable Sickle Cell Disease (SCD)

Inclusion Criteria:

- Age 18 to 50 years

- Subject has a confirmed diagnosis of HbSS or HbSβ0thal

- Subject has stable SCD defined as not having acute VOC, ACS, or other major SCD
associated event during the month prior to enrollment

Exclusion Criteria:

- Subject had an SCD-related VOC or ACS that required hospitalization or treatment in
acute care outpatient setting in the month prior to enrollment

- Subject requires a program of prescheduled regularly administered packed red blood
cell (pRBC) transfusions or Subject received a pRBC transfusion in the month prior to
enrollment

- Subject has evidence of latent or active tuberculosis

- Subject has a major concurrent illness or medical condition

- Subject is pregnant or nursing