A Safety Study of SGN-CD19A for Leukemia and Lymphoma
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Blood Cancer, Lymphoma |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 1 - Any |
| Updated: | 2/4/2017 |
| Start Date: | February 2013 |
| End Date: | May 2019 |
A Phase 1, Open-Label, Dose-Escalation Study of SGN-CD19A in Patients With B-Lineage Acute Lymphoblastic Leukemia and Highly Aggressive Lymphomas
This is a phase 1, open-label, dose-escalation, multicenter study to evaluate the safety and
tolerability of SGN-CD19A in adult and pediatric patients with relapsed or refractory
B-lineage acute lymphoblastic leukemia (B-ALL), Burkitt lymphoma or leukemia, or B-lineage
lymphoblastic lymphoma (B-LBL).
tolerability of SGN-CD19A in adult and pediatric patients with relapsed or refractory
B-lineage acute lymphoblastic leukemia (B-ALL), Burkitt lymphoma or leukemia, or B-lineage
lymphoblastic lymphoma (B-LBL).
Inclusion Criteria:
- Adult patients must be relapsed or refractory to at least 1 prior multi-agent
systemic therapy. Pediatric patients must be relapsed or refractory to at least 2
prior multi-agent systemic therapies. Patients with acute lymphoblastic leukemia who
are Philadelphia chromosome-positive must have failed a second generation tyrosine
kinase inhibitor.
- Eastern Cooperative Oncology Group status of 2 or lower
- Pathologically confirmed diagnosis of B-lineage acute lymphoblastic leukemia, Burkitt
leukemia or lymphoma, or B-lineage lymphoblastic lymphoma
- Measurable disease
Exclusion Criteria:
- Allogeneic stem cell transplant within 60 days, active acute or chronic
graft-versus-host disease (GvHD), or receiving immunosuppressive therapy as treatment
for GvHD
We found this trial at
13
sites
Mayo Clinic Florida Thousands of people come to Mayo Clinic in Jacksonville, Fla., annually for...
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University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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3333 Burnet Avenue # Mlc3008
Cincinnati, Ohio 45229
Cincinnati, Ohio 45229
1-513-636-4200
Cincinnati Children's Hospital Medical Center Patients and families from across the region and around the...
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12902 USF Magnolia Dr
Tampa, Florida 33612
Tampa, Florida 33612
(888) 663-3488
H. Lee Moffitt Cancer Center & Research Institute Moffitt Cancer Center in Tampa, Florida, has...
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Dana-Farber Cancer Institute Since it’s founding in 1947, Dana-Farber has been committed to providing adults...
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Boston Children's Hospital Boston Children's Hospital is a 395-bed comprehensive center for pediatric health care....
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1500 East Duarte Road
Duarte, California 91010
Duarte, California 91010
626-256-HOPE (4673)
City of Hope National Medical Center City of Hope is dedicated to making a difference...
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Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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Mayo Clinic Arizona Mayo Clinic in Arizona provides medical care for thousands of people from...
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All Children's Hospital All Children's Hospital provides expert pediatric care for children and families from...
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