MRI-Guided Cryoablation to Alleviate Pain in Head, Neck and Spine

Nerve ablation is used therapeutically to produce temporary anesthesia and diagnostically to
locate the source of pain. Ablation, or purposeful destruction of tissue, relieves facet
joint pain and pain related to nerve damage by disabling pain-transmitting nerves.
Cryoablation for pain management is particularly useful when other modalities are too
difficult to perform or have a high incidence for complications or side effects.

Currently nerve ablation is performed with bupivacaine and alcohol, but MRI-guided
cryoablation of nerves and facets may result in superior efficacy and longer relief.
Cryotherapy techniques provide long term analgesia and help alleviate intractable pain for
patients with facet joint pain and neuralgia.

Minimally invasive Magnetic Resonance (MR)-guided ablation of nerves and facets may lead to
decreased procedure time and increased relief of pain due to cancer or nerve degeneration.
With the advent of the Advanced Multimodality Image Guided Operating Suite (AMIGO) at the
Brigham and Women's Hospital, we have exceptional capabilities for minimally invasive
image-guided procedures, including different ablation techniques. The AMIGO suite is equipped
with hardware that will keep the patient stationary while the Magnetic Resonance Imaging
scanner moves to the patient. Additionally, the monitoring software within the AMIGO suite
allows clinicians to instantaneously analyze the imaging information which significantly
reduces the risk of injury to adjacent structures.

Inclusion Criteria:

- Participants must be willing and able to sign a written informed consent document.

- Patients must have facet joint disease or pain due to a damaged or compressed nerve
that would benefit from a minimally invasive image-guided procedure (i.e., adjacent to
critical structures, better visualized under 3 Tesla MRI than CT)

- Subjects must be able to adhere to the visit schedules and attend pre and post
imaging.

- Participants must be at least 18 years of age

- Participants must have an estimated life expectancy of >8 weeks in the opinion of the
clinician.

- Patients with radiculopathy must have the cause of pain confirmed by a nerve
block within 3 months prior to ablation

Exclusion Criteria:

- Contraindications to MRI and Gadolinium- (i.e. estimated Glomerular Filtration Rate
<60ml/min, metal clips)

- Pregnant or breastfeeding woman are excluded from this research.