Feasibility of an Evidence-based Walking Program in Cancer Pts 60+ During Chemotherapy
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Breast Cancer, Lung Cancer, Colorectal Cancer, Cancer, Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 60 - Any |
| Updated: | 8/12/2018 |
| Start Date: | October 2012 |
| End Date: | December 2018 |
Feasibility of an Evidence-based Walking Program in a Sample of Cancer Patients >60 Years of Age Undergoing Cytotoxic Chemotherapy
The study will look at conducting a medium-intense walking program called Walk With Ease with
cancer patients age 60 and above who are starting chemotherapy treatment. We will measure how
many of these patients complete their participation in this program.
cancer patients age 60 and above who are starting chemotherapy treatment. We will measure how
many of these patients complete their participation in this program.
The primary purpose of this study is to evaluate the feasibility of implementing a
moderate-intensity walking program (Walk With Ease/WWE) among cancer patients, age ≥60 years,
as they undergo cytotoxic chemotherapy treatment. Feasibility will be determined based on the
rate of participation in the WWE program. As secondary objectives, we will also establish the
rate of completion of a number of instruments, including a Geriatric Assessment tool, and
other instruments that measure self-reported quality of life (e.g., fatigue, depression, and
pain), and self-reported physical activity (PA). Data from these instruments, as well as from
serial measurements of a biomarker of aging (p16INK4a) will be explored and used to inform
future studies designed to evaluate any relationship between these variables and
participation in the WWE program.
We propose a sample (n=30) of cancer patients ≥60 years of age with potentially curable
cancer and a diagnosis of Stage I-III breast cancer, Stage I-III lung cancer, or Stage II-III
colon cancer, who are about to begin chemotherapy. Participation will be defined as
completing the 6-week WWE program. Results from this study will be used in an RO1 application
to the National Cancer Institute (NCI) pertaining to PA interventions among cancer patients
and the effects of biomarkers on prognosis and survival.
moderate-intensity walking program (Walk With Ease/WWE) among cancer patients, age ≥60 years,
as they undergo cytotoxic chemotherapy treatment. Feasibility will be determined based on the
rate of participation in the WWE program. As secondary objectives, we will also establish the
rate of completion of a number of instruments, including a Geriatric Assessment tool, and
other instruments that measure self-reported quality of life (e.g., fatigue, depression, and
pain), and self-reported physical activity (PA). Data from these instruments, as well as from
serial measurements of a biomarker of aging (p16INK4a) will be explored and used to inform
future studies designed to evaluate any relationship between these variables and
participation in the WWE program.
We propose a sample (n=30) of cancer patients ≥60 years of age with potentially curable
cancer and a diagnosis of Stage I-III breast cancer, Stage I-III lung cancer, or Stage II-III
colon cancer, who are about to begin chemotherapy. Participation will be defined as
completing the 6-week WWE program. Results from this study will be used in an RO1 application
to the National Cancer Institute (NCI) pertaining to PA interventions among cancer patients
and the effects of biomarkers on prognosis and survival.
Inclusion Criteria:
- ≥60 years of age, male or female
- Histologically confirmed Stage I, II or III breast cancer (if the patient has had more
than one breast cancer diagnosis, then the most recent diagnosis); Stage I, II or III
lung cancer, or Stage II or III colon cancer
- Scheduled to begin a chemotherapy (or concomitant chemoradiotherapy) regimen that will
last at least 6 weeks in duration
- English speaking
- IRB approved, signed written informed consent
- Approval from their treating physician to engage in moderate-intensity physical
activity
- Patient-assessed ability to walk and engage in moderate physical activity
- Willing and able to meet all study requirements.
Exclusion Criteria:
- One or more significant medical conditions that in the physician's judgment preclude
participation in the walking intervention
- Cancer surgery scheduled within the study period
- Unable to walk or engage in moderate-intensity physical activity
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