Treatment for Presumed Ocular Histoplasmosis

Inclusion Criteria:

- Active choroidal neovascularization (CNV) secondary to presumed ocular histoplasmosis
demonstrated by active leakage on fluorescein angiography with spectal domain OCT
evidence of subretinal or intraretinal fluid or PED.

- Active CNV may also be defined as demonstrating active subretinal hemorrhage.

- ETDRS Best corrected visual acuity 20/20-20/320.

- willing and able to comply with all study clinic visits and study related procedures.

- Willing to use and practice more than one form of contraceptives during the 13 month
study for male and female.

- Provide signed informed consent

- Able to understand and complete study related questionnaires

Exclusion Criteria:

- Under 18 years of age

- CNV due to other causes than Presumed Ocular Histoplasmosis

- Previous treatment in the study eye within 6 months prior to Day 1

- More than 5 Intravitreal injections of anti-VEGF therapy within previous 12 months

- Any clinical evidence of any other ocular condition other than Ocular histoplasmosis

- History of allergy to fluorescein

- Pregnant( or planning on becoming pregnant within the next 13 months) or breast
feeding women

- Sexually Active Men or Women who are NOT willing to practice more than one form of
contraceptives during the next 13 months.

- Anticipated or previous (within previous 3 months) systemic anti-VEGF therapy