Type 2 Diabetes and Exercise Function in Single Leg Exercises
| Status: | Completed |
|---|---|
| Conditions: | Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 30 - 70 |
| Updated: | 6/10/2018 |
| Start Date: | June 2012 |
| End Date: | May 31, 2018 |
Role of Vascular Function: Oxygen Delivery vs Oxygen Utilization in the Exercise Impairment in Type 2 Diabetes
This study plans to learn more about the effects of type 2 diabetes (T2DM) on exercise blood
flow and muscle oxygen uptake. This study will evaluate & compare exercise function during
single leg plantar flexion exercise in a total of 45 subjects from the Denver area (15 lean
controls, 15 people with T2DM, and 15 overweight control subjects).
Differences between the exercise responses in people with T2DM and healthy people will help
further identify the disease process of T2DM and direct future research of treatments and
interventions.
flow and muscle oxygen uptake. This study will evaluate & compare exercise function during
single leg plantar flexion exercise in a total of 45 subjects from the Denver area (15 lean
controls, 15 people with T2DM, and 15 overweight control subjects).
Differences between the exercise responses in people with T2DM and healthy people will help
further identify the disease process of T2DM and direct future research of treatments and
interventions.
It is well established that functional exercise capacity and peak oxygen uptake (VO2) are
reduced in patients with type 2 diabetes mellitus (T2DM) compared with healthy counterparts.
The mechanisms underlying the exercise deficit in T2DM remain largely unknown, but previous
work has suggested that reduced exercise blood flow and impaired submaximal VO2 may be
contributing factors. Both of these findings are consistent with a peripheral impairment of
skeletal muscle oxygen delivery, oxygen utilization, or both. Indeed, dysfunction of skeletal
muscle metabolism plays a key role in the pathophysiology of T2DM, and considerable work has
described abnormalities of oxidative function in the skeletal muscle of people with T2DM.
Given this, it is likely that the causes of exercise intolerance in T2DM may relate to
specific defects at the level of the skeletal muscle, particularly given that skeletal muscle
blood flow and oxidative capacity are impaired in diabetes. However, to our knowledge, no one
has related these peripheral muscle abnormalities to the diminished exercise function in this
patient group.
The overarching hypothesis for the proposed research is that both a failure to adequately
increase muscle oxygen delivery following the onset of exercise and reduced oxidative
function of skeletal muscle contribute to the acute oxygen deficit and diminished exercise
tolerance that has been observed in patients with T2DM.
reduced in patients with type 2 diabetes mellitus (T2DM) compared with healthy counterparts.
The mechanisms underlying the exercise deficit in T2DM remain largely unknown, but previous
work has suggested that reduced exercise blood flow and impaired submaximal VO2 may be
contributing factors. Both of these findings are consistent with a peripheral impairment of
skeletal muscle oxygen delivery, oxygen utilization, or both. Indeed, dysfunction of skeletal
muscle metabolism plays a key role in the pathophysiology of T2DM, and considerable work has
described abnormalities of oxidative function in the skeletal muscle of people with T2DM.
Given this, it is likely that the causes of exercise intolerance in T2DM may relate to
specific defects at the level of the skeletal muscle, particularly given that skeletal muscle
blood flow and oxidative capacity are impaired in diabetes. However, to our knowledge, no one
has related these peripheral muscle abnormalities to the diminished exercise function in this
patient group.
The overarching hypothesis for the proposed research is that both a failure to adequately
increase muscle oxygen delivery following the onset of exercise and reduced oxidative
function of skeletal muscle contribute to the acute oxygen deficit and diminished exercise
tolerance that has been observed in patients with T2DM.
Inclusion Criteria:
- Men and women with and without type 2 diabetes
- 30-70 years of age
- Lean and overweight
- Sedentary subjects not participating in a regular exercise program (
Exclusion Criteria:
- Documented cardiovascular disease
- Uncontrolled hypertension: systolic blood pressure (SBP) > 150, diastolic blood
pressure (DBP)> 110
- Obstructive pulmonary disease or asthma
- Peripheral neuropathy
- Subjects taking beta blockers, insulin, or Thiazolidinediones (TZD)
- Current or past smoking within the last 2 years
- Anemia
- Control HbA1c > 6, T2DM HbA1c > 10
- Type 1 diabetes
- Any implanted metal in subject's body
We found this trial at
1
site
Aurora, Colorado 80045
Principal Investigator: Judith Regensteiner, PhD
Phone: 720-848-6688
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