Effects of Transcranial Direct Current Stimulation (tDCS) on Neuropathic Symptoms Following Burn Injury
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Allergy, Chronic Pain, Chronic Pain, Hospital |
| Therapuetic Areas: | Musculoskeletal, Otolaryngology, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 10/27/2018 |
| Start Date: | January 2013 |
| End Date: | July 2019 |
Boston-Harvard Burn Injury Model System: Cortical Modulation With Transcranial Direct Current Stimulation (tDCS) for Neuropathic Symptoms Following Burn Injury
The purpose of this study is to see the effects of transcranial direct current stimulation
(tDCS) on the pain and itching associated with burn injury. This study is part of the
Boston-Harvard Burn Model System. The investigators hypothesize that there will be a decrease
in pain levels with active stimulation, when compared to sham stimulation, using a 3 week
stimulation schedule- 2 weeks of stimulation (10 consecutive days) followed by 1 week of
stimulation (5 consecutive days) after three follow up visits at 2, 4 and 8 weeks after
initial course of stimulation. The subject will also have follow ups at 2, 4 and 8 weeks
after the second course of stimulation.
If a subject receives sham during the experiment, he/she may enroll in an open-label portion
of the study and receive 10 days of active stimulation.
(tDCS) on the pain and itching associated with burn injury. This study is part of the
Boston-Harvard Burn Model System. The investigators hypothesize that there will be a decrease
in pain levels with active stimulation, when compared to sham stimulation, using a 3 week
stimulation schedule- 2 weeks of stimulation (10 consecutive days) followed by 1 week of
stimulation (5 consecutive days) after three follow up visits at 2, 4 and 8 weeks after
initial course of stimulation. The subject will also have follow ups at 2, 4 and 8 weeks
after the second course of stimulation.
If a subject receives sham during the experiment, he/she may enroll in an open-label portion
of the study and receive 10 days of active stimulation.
Inclusion Criteria:
- Providing informed consent to participate in the study
- Age 18 or older
- Burn injury with pain and/or itch that is moderate to severe
- Burn injury occurring at least 3 weeks prior to enrollment
Exclusion Criteria:
- Subjects with burns in scalp in the area of electrode placement
- Psychiatric disorders that have led to hospitalization within the past 6 months or
signs of suicidality
- Learning disorders that may prevent patient's ability to complete assessments
- Unstable conditions preventing travel to study site
- Current use of any of the following anti-epileptic medications or dopaminergic
medications known to reduce or inhibit the benefits of tDCS treatment: carbamazepine,
oxcarbazepine, phenytoin
- Contraindications to tDCS including implanted metal plates in the head or implanted
brain medical devices
- Pregnancy at time of enrollment
- History of other neurological conditions associated with structural anatomical changes
(i.e. stroke, brain injury, Parkinson's)
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