Ketogenic Diet for Refractory Status Epilepticus

Status:	Recruiting
Conditions:	Neurology, Epilepsy
Therapuetic Areas:	Neurology, Other
Healthy:	No
Age Range:	18 - 80
Updated:	4/21/2016
Start Date:	November 2012
Contact:	Mackenzie C. Cervenka, M.D.
Email:	mcerven1@jhmi.edu
Phone:	443-287-0423

Feasibility and Tolerability of the Ketogenic Diet in the Treatment of Refractory Status Epilepticus in a Neurointensive Care Unit.

This research is being done to observe the safety, tolerability, side effects, and
effectiveness of the ketogenic diet in people with continuous seizures (status epilepticus)
being treated in a neurointensive care unit.

Inclusion Criteria:

- Patients 18 years and older in refractory status epilepticus (continuous or recurrent
seizures without return to baseline mental status between seizures, lasting > 30
minutes) placed on anesthetics/sedating agents (barbiturates or benzodiazepines)
after at least one first- and second-line agent failed to control seizures, and with
clinical and/or electrographic seizures following attempt to wean anesthetic/sedating
agents after 24 hours.

Exclusion Criteria:

1. Unstable metabolic condition

2. Hemodynamic or cardiorespiratory instability

3. Coagulopathy

4. Liver failure

5. Total cholesterol > 300 mg/dL

6. Inability to tolerate enteral feeds, including ileus

7. Pregnancy

8. Family refusal/no consent

9. Received any propofol infusions within 24 hours

10. Known fatty acid oxidation disorder or pyruvate carboxylase deficiency

We found this trial at

sites

Rush University Medical Center

1653 W. Congress Parkway
Chicago, Illinois 60612

(312) 942-5000