A Study of Alectinib (RO5424802) in Participants With Non-Small Cell Lung Cancer Who Have Anaplastic Lymphoma Kinase (ALK) Mutation and Failed Crizotinib Treatment

Status:	Completed
Conditions:	Lung Cancer, Cancer
Therapuetic Areas:	Oncology
Healthy:	No
Age Range:	18 - Any
Updated:	11/4/2018
Start Date:	June 20, 2013
End Date:	October 27, 2017

An Open-Label, Non-Randomized, Multicenter Phase I/II Trial of RO5424802 Given Orally to Non-Small Cell Lung Cancer Patients Who Have ALK Mutation and Who Have Failed Crizotinib Treatment

This open-label, non-randomized, multicenter, Phase 1/2 study will evaluate the safety and
efficacy of alectinib in participants with non-small cell lung cancer who have ALK mutation
and failed crizotinib treatment. In Part 1, cohorts of participants will receive escalating
doses of alectinib orally twice daily. In Part 2, participants will receive the recommended
phase 2 dose (RP2D) of alectinib as determined in Part 1. Treatment will continue in Part 1
and Part 2 on the same dose until disease progression. In Part 3, following disease
progression, participants without epidermal growth factor receptor (EGFR) mutation will be
offered continued treatment with alectinib, participants with EGFR mutations will be offered
a combination of alectinib and erlotinib.

Inclusion Criteria:

- Locally advanced or metastatic non-small cell lung cancer (stage IIIB or IV by
American Joint Committee on Cancer [AJCC])

- Eastern Cooperative Oncology Group (ECOG) performance status 0-2

- Documented ALK rearrangement based on Food and Drug Administration (FDA)-approved test

- Prior treatment with crizotinib and progression according to response evaluation
criteria in solid tumors version 1.1 (RECIST v1.1) criteria. Participants had to have
a minimum 1-week wash-out period between the last dose of crizotinib and the first
dose of study treatment. Participants can either be chemotherapy-naïve or have
received at least one line of platinum-based chemotherapy

- Adequate hematologic, hepatic, and renal function

- Participants with brain or leptomeningeal metastases are allowed if protocol defined
criteria are met

- Measurable disease according to RECIST v1.1 prior to administration of first dose of
study drug

Exclusion Criteria:

- Receipt of any other ALK inhibitors in addition to crizotinib

- Receipt of any prior cytotoxic chemotherapy for ALK-positive NSCLC within 4 weeks
prior to the first dose of study drug

- Participants who received crizotinib or any other tyrosine kinase inhibitors need to
have a minimum 1-week washout period before the first dose of study drug

- Active or uncontrolled infectious diseases requiring treatment

- National Cancer Institute Common Terminology Criteria for Adverse Events version 4.03
(NCI CTCAE v4.03) Grade 3 or higher toxicities due to prior therapy that have not
shown improvement and are considered to interfere with current study medication

- History of organ transplant

- Co-administration of anti-cancer therapies other than those administered in this study

- Baseline corrected Q-T interval (QTc) greater than (>) 470 milliseconds, or baseline
symptomatic bradycardia (less than 45 heart beats per minute)

- Pregnant or breastfeeding women

- Known Human Immunodeficiency Virus (HIV) positivity or Acquired Immunodeficiency
Syndrome (AIDS)-related illness

- History of hypersensitivity to any of the additives in the alectinib formulation

- Any clinically significant concomitant disease or condition that could interfere with,
or for which treatment might interfere with, the conduct of the study, or absorption
of oral medications, or that would, in the opinion of the principal investigator, pose
an unacceptable risk to the participant in the study

We found this trial at

sites

St. Jude Heritage Healthcare

Fullerton, California 92835

from

Fullerton, CA