Walking Interventions, Cognitive Remediation and Mild Cognitive Impairment

This is a single blind randomized study designed to understand the effects of different
interventions, walking interventions and cognitive remediation in particular, towards
cognition and gait in the elderly. The study uses a 4 arm approach consisting of 4
intervention groups, with each intervention lasting for 12 weeks. The investigators will
investigate the effect of each intervention towards cognitive function and gait. All
interventions will be conducted on site at the Pennington Biomedical Research Center, and
will be focused on determining the effects of different combinations of walking, cognitive
remediation, healthy living courses, and reading. Cognitive measures will include objective
clinical measures related to dementia, and the gait analysis will include in clinic and
"free living" measures related to falls.

Inclusion Criteria:

- Men and women meeting all criteria listed below will be included in the study:

- Subjects between 65-85 years of age inclusive

- Subjects with Short Physical Performance Battery of 10 or greater

- Subjects averaging less than 5,000 steps per day

- Subjects with Mini Mental State Exam 25-28, inclusive

- Subjects with normal for age physical-neurological exam

- Subjects able to walk a city block without a walking aid

- Written Informed Consent obtained PRIOR to performing any study procedures

Exclusion Criteria:

- Subjects with difficult walking due to pain or posture

- Subjects with difficulty in using computer due to significant visual and/or fine
motor impairment

- Subjects with large weight loss (>15 Kilogram) in the last 12 months

- Subjects with geriatric depression scale > 9.

- Subjects with Malignancies in the past 5 years, with the exception of skin cancer
therapeutically controlled

- Subjects with abnormal electrocardiogram results. These include: a resting heart rate
below 40 bpm or above 100 bpm, previously unknown and/or untreated atrial
fibrillation or flutter, evidence of a third degree A-V block, a previously
undocumented left bundle branch block, S-T segment depression of greater than 2 mm,
evidence of a previous MI, or any other findings that in the clinical judgment of the
medical investigator preclude participation in an exercise intervention.

- Subjects with shortness of breath, exertional angina, uncontrolled high blood
pressure or any other chronic medical condition deemed by the physician to preclude
participation in an exercise intervention.

- Subjects with any other medical condition or disease that is life-threatening or that
can interfere with, or be aggravated by, exercise.

- Subjects who currently smoke.