Single Dose Escalation Study of GSK2838232 in Healthy Subjects

Inclusion Criteria

- Healthy as determined by a responsible and experienced physician, based on a medical
evaluation including medical history, physical examination, laboratory tests and
cardiac monitoring. A subject with a clinically significant abnormality or laboratory
parameters outside the reference range for the population being studied may be
included only if the Investigator and the GSK Medical Monitor agree that the finding
is unlikely to introduce additional risk factors and will not interfere with the
study procedures

- Male or female between 18 and 50 years of age inclusive, at the time of signing the
informed consent. A female subject is eligible to participate if she is of
non-childbearing potential defined as pre-menopausal females with a documented tubal
ligation or hysterectomy; or postmenopausal defined as 12 months of spontaneous
amenorrhea (in questionable cases a blood sample with simultaneous follicle
stimulating hormone >40 milli international unit [MlU]/milliliter [mL] and estradiol
<40 picogram [pg]/mL [<147 picomoles /liter] is confirmatory).

- Body weight >= 50 kilograms (kg) (110 pounds.) for men and >= 45 kg (99 pounds) for
women and body mass index (BMI) within the range 18.5 to 31.0 kg/meter^2 (inclusive).

- A Creatinine clearance (CLcr) >80 mL/minute (min) as determined by Cockcroft-Gault
equation. CLcr (mL/min) = (140 - age) x weight / (72 x serum creatinine [Scr]) (times
0.85 if female) where age is in years, weight is in kg, and Scr is in units of
milligram (mg)/deciliter (dL).

- Male subjects with female partners of child-bearing potential must agree to use
contraception method. This criterion must be followed from the time of the first dose
of study medication until the follow up visit.

- Subject must be capable of giving written informed consent, which includes compliance
with the requirements and restrictions listed in the consent form.

Exclusion Criteria

- A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody
result within 3 months of screening.

- Alanine aminotransferase (ALT), alkaline phosphatase and bilirubin >= 1.5x Upper
limit of normal (ULN) (isolated bilirubin >1.5xULN is acceptable if bilirubin is
fractionated and direct bilirubin <35 percent).

- Screening or baseline cardiac troponin I greater than the 99 percent cutoff (>.045
nanogram [ng]/mL by the Dimension Vista cardiac troponin I [CTNI] assay).

- Screening BNP greater than the upper limit of normal

- Current or chronic history of liver disease, or known hepatic or biliary
abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones).

- A positive pre-study drug/alcohol screen.

- A positive test for Human Immuno Virus antibody.

- History of regular alcohol consumption within 6 months of the study defined as an
average weekly intake of >14 drinks for males or >7 drinks for females. One drink is
equivalent to 12 grams of alcohol: 12 ounces (360 mL) of beer, 5 ounces (150 mL) of
wine or 1.5 ounces (45 mL) of 80 proof distilled spirits.

- The subject has participated in a clinical trial and has received an investigational
product within the following time period prior to the first dosing day in the current
study: 30 days, 5 half-lives or twice the duration of the biological effect of the
investigational product (whichever is longer).

- Exposure to more than four new chemical entities within 12 months prior to the first
dosing day.

- Unable to refrain from the use of prescription or non-prescription drugs, including
vitamins, herbal and dietary supplements (including St John's Wort) within 7 days (or
14 days if the drug is a potential enzyme inducer) or 5 half-lives (whichever is
longer) prior to the first dose of study medication, unless in the opinion of the
Investigator and GlaxoSmithKline (GSK) Medical Monitor the medication will not
interfere with the study procedures or compromise subject safety.

- History of sensitivity to any of the study medications, or components thereof or a
history of drug or other allergy that, in the opinion of the investigator or GSK
Medical Monitor, contraindicates their participation.

- Where participation in the study would result in donation of blood or blood products
in excess of 500 mL within a 56 day period.

- Pregnant females as determined by positive urine or serum human chorionic
gonadotropin (hCG) test at screening or prior to dosing on Day 1.

- Lactating females.

- History of sensitivity to heparin or heparin-induced thrombocytopenia.

- Subjects who have asthma or a history of asthma

- A history of or regular use of tobacco- or nicotine-containing products within 6
months prior to screening.

- Unable to refrain from consumption of red wine, seville oranges, grapefruit or
grapefruit juice and/or pummelos, exotic citrus fruits, grapefruit hybrids or fruit
juices from 7 days prior to the first dose of study medication.

- Subjects with a pre-existing condition interfering with normal gastrointestinal
anatomy or motility, hepatic and/or renal function, that could interfere with the
absorption, metabolism, and/or excretion of the study drugs. Subjects with a history
of cholecystectomy should be excluded.

- Exclusion Criteria for 24-Hour Screening Holter are: any symptomatic arrhythmia
(except isolated extra systoles), sustained cardiac arrhythmias (such as atrial
fibrillation or flutter, supraventricular tachycardia (>=10 consecutive beats),
complete heart block), non-sustained or sustained ventricular tachycardia (defined as
>= 3 consecutive ventricular ectopic beats), any conduction abnormality (including
but not specific to left or right incomplete or complete bundle branch block,
atrioventricular (AV) block [2nd degree or higher], Wolff-Parkinson-White
[WPW]syndrome etc.), sinus Pauses > 3 seconds, 300 or more supraventricular ectopic
beats in 24 hours, and 250 or more ventricular ectopic beats in 24 hours.

- Exclusion criteria for screening ECG (a single repeat is allowed for eligibility
determination) are: Male subjects with Heart rate <45 and >100 beats per minute (bpm)
and female subjects with heart rate <50 and >100 bpm, PR <120 and >220 milliseconds
(msec), QRS duration <70 and >120 msec, QT interval corrected for heart rate
(Fridericia's) >450 msec. (Note: A heart rate from 100 to 110 bpm can be rechecked by
ECG or vitals within 30 minutes to verify eligibility).

Evidence of previous myocardial infarction (Does not include ST segment changes associated
with repolarization).

Any conduction abnormality (including but not specific to left or right complete bundle
branch block, AV block [2nd degree or higher], WPW syndrome).

Sinus Pauses > 3 seconds. Any significant arrhythmia which, in the opinion of the
principal investigator OR GSK medical monitor, will interfere with the safety for the
individual subject.

Non-sustained or sustained ventricular tachycardia (>=3 consecutive ventricular ectopic
beats).

- Medical history of cardiac arrhythmias or cardiac disease or a family and personal
history of long QT syndrome.

- Any clinically significant abnormal echocardiogram finding. Abnormal echocardiogram
findings should be discussed with the Medical Monitor prior to enrolment.