Exercise Training in Depressed Traumatic Brain Injury Survivors
| Status: | Withdrawn |
|---|---|
| Conditions: | Depression, Hospital, Neurology |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology, Other |
| Healthy: | No |
| Age Range: | 14 - 65 |
| Updated: | 4/21/2016 |
| Start Date: | February 2013 |
| End Date: | June 2014 |
The purpose of this study is to determine the feasibility of successfully delivering
moderate intensity aerobic exercise training to depressed traumatic brain injury subjects
between one and three years after injury.
moderate intensity aerobic exercise training to depressed traumatic brain injury subjects
between one and three years after injury.
Traumatic brain injury (TBI) alters the lives of many civilians and those involved in armed
conflicts. Sequelae of TBI includes depression in up to 30% of cases. Appearance of
depression after TBI impairs recovery and results in sub-optimal re-integration into
society. Treatment of post TBI depression relies on oral medications, whose efficacy and
side effect profile is sub-optimal. Exercise training is effective in spontaneous depression
as a stand alone treatment and in conjunction with oral medications, and this may represent
an alternative treatment option in the TBI population. Further, the pathophysiology of
depression after TBI has yet to be examined with the full scientific rigor required. This
project proposes to use exercise training of moderate intensity as a treatment for
depression after TBI, while measuring biological markers as a way to investigate efficacy
and provide insight into the pathophysiology.
conflicts. Sequelae of TBI includes depression in up to 30% of cases. Appearance of
depression after TBI impairs recovery and results in sub-optimal re-integration into
society. Treatment of post TBI depression relies on oral medications, whose efficacy and
side effect profile is sub-optimal. Exercise training is effective in spontaneous depression
as a stand alone treatment and in conjunction with oral medications, and this may represent
an alternative treatment option in the TBI population. Further, the pathophysiology of
depression after TBI has yet to be examined with the full scientific rigor required. This
project proposes to use exercise training of moderate intensity as a treatment for
depression after TBI, while measuring biological markers as a way to investigate efficacy
and provide insight into the pathophysiology.
Inclusion Criteria:
- CT brain with subdural hematoma, subarachnoid hemorrhage, and/or cortical contusion
- Glasgow outcome scale extended of 4 to 8
- speaks English
- Beck Depression Inventory -II score between 14 and 28
- sedentary life style
- one to three years after traumatic brain injury
Exclusion Criteria:
- prior history of brain process (example, stroke, brain tumor)
- aphasia
- psychosis, mania, bipolar disorder, schizophrenia
- pregnancy
- inability to exercise via cycles or treadmill
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Virginia Commonwealth University Since our founding as a medical school in 1838, Virginia Commonwealth University...
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