Neural Functioning of Feeding Centers in Obese Youth

Functional Magnetic Resonance Imaging (fMRI) provides a non-invasive method to assess the
functional pathways affected by nutrient ingestion and therefore can help answer important
questions regarding potential differences in the response of brain regions involved in
feeding.

Inclusion Criteria:

- Obese adolescents

- Good general health,

- taking no medication on a chronic basis

- Age 12 to 17 yrs,

- in puberty (girls and boys: Tanner stage II - IV)

Obese Insulin Resistant Adolescents

- (BMI> 95th)

- (WBISI<1.2 plus a low adiponectin <6 ug/dl and

- high triglyceride levels >130mg/dl)

Obese Insulin Sensitive Adolescents

- (BMI>95th)

- (WBISI >3) plus high adiponectin >8 ug/ml and

- triglyceride levels > 80 mg/dl Girls who begin menstruating must have a negative
pregnancy test during the study

Eligibility criteria for healthy non-obese children and adolescents:

- Brother or sister with obesity

- Age 12 to 17 years

- Normal fasting glucose and lipids in the child, and

- normal OGTT

- No use of any medication known to affect glucose, lipid metabolism and inflammation

- No endocrinopathies

- No use of any antipsychotic medication

- BMI >25th to <75th ( Center for Disease Control (CDC) BMI Charts)

- Minimum weight of 90lbs (CDC Growth Charts)

Exclusion Criteria

- Baseline creatinine >1.0 mg

- Pregnancy

- Presence of endocrinopathies (e.g. Cushing syndrome)

- Cardiac or pulmonary or other significant chronic illness

- Adolescents with psychiatric disorder or with substance abuse determined via
self-report.

- Use of anorexic agents No metal implants