Study of Individuals and Families at High Risk for Testicular Cancer

OBJECTIVES:

- Identify new families with familial testicular germ cell tumors (TGCT).

- Determine the clinical features of familial TGCT.

- Determine the underlying genetic mechanism for susceptibility to familial TGCT.

- Determine the various parameters related to psychosocial and behavioral issues
resulting from being a member of a family at increased risk of TGCT.

OUTLINE: This is a two-part study.

- Part 1 (genetic study): Participants contribute DNA for analysis. Participants also
complete personal and family medical history, risk factor exposure, and psychosocial
and behavioral questionnaires.

- Part 2 (etiology study): Participants undergo clinical evaluation including physical
exam, blood tests, and imaging studies (CT scan or MRI and ultrasound) of the chest,
abdomen, pelvis, and gonads.

A certificate of confidentiality protecting the identity of research participants in this
project has been issued by the National Cancer Institute.

Participants do not receive the results of the genetic analysis, which is aimed at finding
new testicular cancer susceptibility genes. The results do not influence the type or
duration of treatment. Genetic testing for mutations in known genes cannot be performed, as
none of these genes have yet been identified.

Participants are followed annually for 5 years.

PROJECTED ACCRUAL: Approximately 750 participants will be accrued for this study within 5
years.