A New Diet for Patients With Autosomal Dominant Polycystic Disease (ADPKD)
| Status: | Completed |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease |
| Therapuetic Areas: | Nephrology / Urology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 4/21/2016 |
| Start Date: | February 2013 |
| End Date: | November 2014 |
Recent evidence has shown that kidney volume predicts the likelihood of developing renal
insufficiency over a finite length of time in ADPKD, suggesting a linkage between the growth
of cysts and the harm they do to kidney function. Recent studies indicate that the rate of
kidney volume increase is hastened by excess dietary protein, salt, and potential net acid
precursors, and slowed by increased water intake sufficient to lower plasma vasopressin
levels.
Diets are commonly prescribed to treat ADPKD and other renal patients with disease near the
end-stage, but there is currently no specific diet prescription that takes potentially
harmful dietary elements into account for ADPKD patients in the earliest stages of the
disease. This study will examine a novel diet for ADPKD created by the researcher termed the
ADPKD diet.
insufficiency over a finite length of time in ADPKD, suggesting a linkage between the growth
of cysts and the harm they do to kidney function. Recent studies indicate that the rate of
kidney volume increase is hastened by excess dietary protein, salt, and potential net acid
precursors, and slowed by increased water intake sufficient to lower plasma vasopressin
levels.
Diets are commonly prescribed to treat ADPKD and other renal patients with disease near the
end-stage, but there is currently no specific diet prescription that takes potentially
harmful dietary elements into account for ADPKD patients in the earliest stages of the
disease. This study will examine a novel diet for ADPKD created by the researcher termed the
ADPKD diet.
Inclusion Criteria:
- Have not been prescribed dietary restrictions or enhancements
- Blood pressure <135/85 mmHg with or without specific treatment
- Willingness to participate for at least one month
- Diet history consistent with the excretion of >30 mEq NAE / day based on usual
dietary intake
Exclusion Criteria:
- Other active diseases requiring pharmacologic agents
- Unstable weight (+/- 2 kg) for 3 months prior to enrollment
- Food allergies
- Pregnancy or lactating
- Confounding medications, i.e. bicarbonate, citrate
- Individuals who do not consume meat for personal, religious, or health reasons.
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