The Use of Microneedles in Photodynamic Therapy
| Status: | Recruiting |
|---|---|
| Conditions: | Dermatology |
| Therapuetic Areas: | Dermatology / Plastic Surgery |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 5/5/2014 |
| Start Date: | July 2012 |
| Contact: | Lam Nguyen, CCRP |
| Email: | lam.nguyen@ucdmc.ucdavis.edu |
| Phone: | 916.734.6556 |
The global aim of this study is to investigate how microneedles can facilitate the
penetration and efficacy of photodynamic therapy in the treatment of actinic keratoses
The specific aims are as follows:
1. Investigate whether pretreatment with microneedles enhances penetration of topical
aminolevulinic acid (ALA) that is marketed as Levulan® Kerasticks by DUSA
pharmaceuticals Inc.
2. Investigate whether pretreatment with microneedles can decrease the required incubation
times of the topical ALA prior to exposure to blue light photodynamic therapy.
penetration and efficacy of photodynamic therapy in the treatment of actinic keratoses
The specific aims are as follows:
1. Investigate whether pretreatment with microneedles enhances penetration of topical
aminolevulinic acid (ALA) that is marketed as Levulan® Kerasticks by DUSA
pharmaceuticals Inc.
2. Investigate whether pretreatment with microneedles can decrease the required incubation
times of the topical ALA prior to exposure to blue light photodynamic therapy.
Inclusion Criteria:
1. Subjects who are 18 and older
2. Subjects who have at least 3 actinic keratoses on each side of the forehead
3. Subjects who signed an IRB approved informed consent
Exclusion Criteria:
1. Subjects who smoke
2. Subjects who have a photosensitizing condition such as lupus, porphyria, or similar
condition.
3. Subjects who received a diagnosis of skin cancer on the face in past year
4. Subjects who received field treatment for actinic keratoses to the face in the past
60 days
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