Role of Neutrophil Activation
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 4/6/2017 |
| Start Date: | March 2013 |
| End Date: | April 2018 |
Sore Throat Secondary to Endotracheal Intubation: the Role of Neutrophil Activation
Patients will undergo placement of an endotracheal tube (ETT) as standard of care. Tracheal
lavage will be conducted using 5 mL of sterile saline solution by a push/suction technique.
Specimen samples obtained by wall suction will be collected at 2 time points following
intubation.
Blood samples will be obtained at 2 time points, simultaneous with the collection of the
tracheal specimens.
lavage will be conducted using 5 mL of sterile saline solution by a push/suction technique.
Specimen samples obtained by wall suction will be collected at 2 time points following
intubation.
Blood samples will be obtained at 2 time points, simultaneous with the collection of the
tracheal specimens.
Inclusion Criteria
1. Ages 18 to 65
2. American Society of Anesthesiologists Physical Status Classification (ASA) I and II
3. Required to have endotracheal intubation
4. Scheduled for short admission (<23 hrs), or ambulatory orthopedic surgery (ankle,
shoulder, or extremity surgery); general surgery (exploratory laparotomy,
cholecystectomy, ventral or inguinal hernia repair); obstetric/gynecological
surgery(total abdominal hysterectomy, bilateral salpingo-oophorectomy); urologic
surgery (nephrectomy, prostatectomy), lumbar spine surgery( discectomy, one or two
level lumbar fusion) procedures.
5. Estimated duration of surgery 3 to 4 hours.
6. Provide informed consent
Exclusion Criteria
1. Active pulmonary disease within 5 days prior to enrollment
2. On immunosuppressive medications
3. Previous tracheal surgery
4. On azithromycin
5. Diabetes
6. Pregnancy
7. Smoking history of less than 6 weeks prior to surgery
8. Surgery or intubation within 5 days of surgery
9. Planned surgical procedure involving neck or thoracic regions
10. Active pulmonary disease
11. Autoimmune disease (HIV, AIDS, Rheumatoid Arthritis
12. Hepatitis
13. Cancer
We found this trial at
1
site
St. Louis, Missouri 63108
Principal Investigator: Carlos A Puyo, MD, FCCP
Phone: 314-747-0259
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