Cough-Generated Aerosols of NTM in Cystic Fibrosis
| Status: | Completed |
|---|---|
| Conditions: | Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 8 - 75 |
| Updated: | 4/21/2016 |
| Start Date: | April 2013 |
| End Date: | July 2015 |
Cough-Generated Aerosols of Nontuberculous Mycobacteria in Patients With Cystic Fibrosis
Non-tuberculous mycobacteria (NTM) are opportunistic pathogens normally found in soil and
water that are being cultured from Cystic Fibrosis (CF) airways at an increasing frequency.
They have been demonstrated to cause clinically significant lung disease in some cases and
the transmission of NTM, from person to person has been proposed. There are currently no
standardized guidelines for isolation of those colonized or infected with NTM.
The investigators will measure particle droplet size from patients with CF who have positive
sputum cultures for NTM with the hypothesis that they will be in a range that can spread
infection.
water that are being cultured from Cystic Fibrosis (CF) airways at an increasing frequency.
They have been demonstrated to cause clinically significant lung disease in some cases and
the transmission of NTM, from person to person has been proposed. There are currently no
standardized guidelines for isolation of those colonized or infected with NTM.
The investigators will measure particle droplet size from patients with CF who have positive
sputum cultures for NTM with the hypothesis that they will be in a range that can spread
infection.
Patients with a positive NTM sputum culture will be asked to participate in the study. If
they agree to participate they will sign an informed consent and will be scheduled to come
to the University of Florida Clinical Research Center for the testing.
The test will consist of the following: pulmonary function test, collecting a sputum culture
if possible, coughing for 5 minutes into a tube connected to a canister, hypertonic saline
and albuterol will be given after the 5 minutes of coughing and then they would repeat with
another 5 minutes of coughing. There can be a break inbetween the coughing if needed.
Patients maybe asked to come back a second time if they develop a different type of NTM or
start treatment for NTM.
they agree to participate they will sign an informed consent and will be scheduled to come
to the University of Florida Clinical Research Center for the testing.
The test will consist of the following: pulmonary function test, collecting a sputum culture
if possible, coughing for 5 minutes into a tube connected to a canister, hypertonic saline
and albuterol will be given after the 5 minutes of coughing and then they would repeat with
another 5 minutes of coughing. There can be a break inbetween the coughing if needed.
Patients maybe asked to come back a second time if they develop a different type of NTM or
start treatment for NTM.
Inclusion Criteria:
- Age greater than or equal to age 8 years
- Confirmed Diagnosis of CF
- Sputum/Throat/Bronchoscopic culture positive for NTM within the last 12 months
Exclusion Criteria:
- Pregnancy
- Pneumothorax within the last 6 months
- Forced Expiratory Volume at one second <30% predicted
- Hemoptysis greater than 1 tablespoon within the last 7 days
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