Assessment of Mandibular Bone Invasion With MRI Using SWIFT
| Status: | Enrolling by invitation |
|---|---|
| Conditions: | Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 10/25/2017 |
| Start Date: | April 2013 |
| End Date: | December 2017 |
Assessment of Mandibular Bone Invasion With Magnetic Resonance Imaging (MRI) Using Sweep Imaging Fourier Transformation (SWIFT)
The primary objective of this study is to improve the diagnostic accuracy and specificity of
MRI in detecting the degree of bone involvement and invasion in oral cancer. The presence and
degree of bone invasion determines the extent of surgery and has great effect on the
morbidity of patients with oral cancer and bone/soft tissue tumors.
MRI scanning in 3 Tesla (3T) and 4Tesla (4T) MR magnet will be performed on up to 10 patients
with possible maxillofacial and/or mandibular bone invasion. We will then compare the
conventional imaging results of the patients with 3T and 4T MRI results and post operative
pathology results.
MRI in detecting the degree of bone involvement and invasion in oral cancer. The presence and
degree of bone invasion determines the extent of surgery and has great effect on the
morbidity of patients with oral cancer and bone/soft tissue tumors.
MRI scanning in 3 Tesla (3T) and 4Tesla (4T) MR magnet will be performed on up to 10 patients
with possible maxillofacial and/or mandibular bone invasion. We will then compare the
conventional imaging results of the patients with 3T and 4T MRI results and post operative
pathology results.
Unfortunately, detecting bone invasion and extension of bone involvement prior to surgery is
often difficult with the currently available imaging techniques. MRI with high contrast
resolution and the ability to perform multiplanar imaging plays an integral role in the
delineation of tumoral involvement of the bone. Although MRI is an excellent tool in the
assessment of bone invasion in carcinoma, its overestimation of cortical invasion and tumor
extent to the bone marrow have been a diagnostic challenge, leading to false positive
results. Like many of the musculoskeletal system tissues, cortical bone produces no signal
with conventional MRI techniques, limiting the characterization of image contrast and
differentiation of adjacent soft tissues. A novel MRI technique called Sweep Imaging with
Fourier Transformation (SWIFT) appears to be a suitable tool to overcome this challenge. The
main advantage of SWIFT is to obtain signal from the cortical bone. We believe that the SWIFT
technique will overcome the false positive results.
Patients enrolled in this study will be asked to come to the Center for Magnetic Resonance
Research (CMRR) at the University of Minnesota, Minneapolis, Minnesota for a scheduled MRI.
Brief scans will be obtained (less than 1 minute) to localize the area of interest. Longer
MRI scans (around 5-15 minutes each) will then be obtained. The total time required for
scanning will be about 1 hour.
To determine how well our MR images will predict the presence of mandibular invasion, we will
compare our results with clinical, operative, radiological and pathological findings. Thus,
patients will be asked to give permission to the investigators to access the relevant medical
records.
often difficult with the currently available imaging techniques. MRI with high contrast
resolution and the ability to perform multiplanar imaging plays an integral role in the
delineation of tumoral involvement of the bone. Although MRI is an excellent tool in the
assessment of bone invasion in carcinoma, its overestimation of cortical invasion and tumor
extent to the bone marrow have been a diagnostic challenge, leading to false positive
results. Like many of the musculoskeletal system tissues, cortical bone produces no signal
with conventional MRI techniques, limiting the characterization of image contrast and
differentiation of adjacent soft tissues. A novel MRI technique called Sweep Imaging with
Fourier Transformation (SWIFT) appears to be a suitable tool to overcome this challenge. The
main advantage of SWIFT is to obtain signal from the cortical bone. We believe that the SWIFT
technique will overcome the false positive results.
Patients enrolled in this study will be asked to come to the Center for Magnetic Resonance
Research (CMRR) at the University of Minnesota, Minneapolis, Minnesota for a scheduled MRI.
Brief scans will be obtained (less than 1 minute) to localize the area of interest. Longer
MRI scans (around 5-15 minutes each) will then be obtained. The total time required for
scanning will be about 1 hour.
To determine how well our MR images will predict the presence of mandibular invasion, we will
compare our results with clinical, operative, radiological and pathological findings. Thus,
patients will be asked to give permission to the investigators to access the relevant medical
records.
Inclusion Criteria:
- Patients with a diagnosis of oral cancer with clinical or imaging findings suggestive
of maxillofacial or mandibular bone invasion.
- Patients who will be undergoing surgery as treatment for their oral cancer.
Exclusion Criteria:
- Pregnancy
- Ferromagnetic implant
- History of shotgun wounds and shrapnel
- Obesity (>250 pounds)
- Cardiac pacemaker
- MR incompatible medical device
- Severe claustrophobia
- Surgeries with potential ferromagnetic implants
- Metallic ink tattoo in close proximity to area of interest.
We found this trial at
1
site
Univ of Minnesota With a flagship campus in the heart of the Twin Cities, and...
Click here to add this to my saved trials
