Study Evaluating Inotuzumab Ozogamicin [CMC-544] Administered In Combination With Rituximab In Subjects With Non-Hodgkin's Lymphoma (NHL)
| Status: | Completed |
|---|---|
| Conditions: | Lymphoma |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/17/2018 |
| Start Date: | May 4, 2006 |
| End Date: | June 2, 2014 |
A Phase 1/2 Study Of Cmc-544 Administered In Combination With Rituximab In Subjects With Follicular Or Diffuse Large B-cell Non-hodgkin's Lymphoma
The purpose of the study is to determine the tolerability, the initial safety profile and
maximum tolerated dose, and to obtain preliminary information on the antitumor activity of
inotuzumab ozogamicin [CMC-544] in combination with rituximab in subjects with follicular,
diffuse large B-Cell, or mantle cell NHL.
maximum tolerated dose, and to obtain preliminary information on the antitumor activity of
inotuzumab ozogamicin [CMC-544] in combination with rituximab in subjects with follicular,
diffuse large B-Cell, or mantle cell NHL.
Inclusion Criteria:
- Subjects with CD20 and CD22-positive, follicular or diffuse large B-cell NHL who have
not responded or progressed after 1 or 2 prior therapies; or subjects with CD20 and
CD22-positive intermediate/aggressive NHL (diffuse large B-cell, mantle cell,
transformed follicular or follicular grade 3b NHL) who have not responded or
progressed after 1 or more prior therapies and are refractory to a previous rituximab
containing therapy.
- Prior therapy must contain at least one course of rituximab therapy, as single agent
or in combination.
- Measurable disease.
Exclusion Criteria:
- Subjects who are candidates for other potentially curative therapies.
- Subjects must not have received previous radioimmunotherapy.
- Subjects who have undergone a prior bone marrow transplantation within the last 6
months.
We found this trial at
19
sites
Gabrail Cancer Center Since 1990, Gabrail Cancer Center has built a national reputation for excellence...
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University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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Cleveland Clinic Cleveland Clinic is committed to principles as presented in the United Nations Global...
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Emory University Hospital As the largest health care system in Georgia and the only health...
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University Hospitals of Cleveland The history of University Hospitals Case Medical Center is linked to...
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1515 Holcombe Blvd
Houston, Texas 77030
Houston, Texas 77030
713-792-2121
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
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