Dose-Ranging Study Of Tofacitinib In Adults With Active Ankylosing Spondylitis



Status:Completed
Conditions:Arthritis, Neurology
Therapuetic Areas:Neurology, Rheumatology
Healthy:No
Age Range:18 - Any
Updated:4/13/2015
Start Date:April 2013
End Date:March 2015
Contact:Pfizer CT.gov Call Center
Phone:1-800-718-1021

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase 2, Randomized, Double-blind, Placebo-controlled, Dose-ranging Study Of The Efficacy And Safety Of Tofacitinib In Subjects With Active Ankylosing Spondylitis (as)

This is the first study of oral tofacitinib in adults with active ankylosing spondylitis.
It is designed to obtain information on the efficacy and safety of 3 different doses of
tofacitinib.


Inclusion Criteria:

- Documented diagnosis of Ankylosing Spondylitis

- Has active disease despite concurrent nonsteroidal anti-inflammatory drugs (NSAIDs)
treatment or is intolerant to NSAIDs

Exclusion Criteria:

- Pregnant or lactating females

- Currently receiving or previous use of a Tumor Necrosis Factor (TNF) inhibitor or any
biological agent
We found this trial at
18
sites
Millennium Research
Ormond Beach, Florida 32174
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Ormond Beach, FL
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Oregon Health and Science University
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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Portland, OR
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Joint and Muscle Research Institute
Charlotte, North Carolina 28204
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from
Charlotte, NC
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Presbyterian Imaging
Charlotte, North Carolina 28207
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mi
from
Charlotte, NC
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Arthritis & Rheumatology Associates
Clearwater, Florida 33756
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from
Clearwater, FL
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Altoona Center for Clinical Research
Duncansville, Pennsylvania 16635
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Duncansville, PA
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Klein & Associates MD, PA.
Hagerstown, Maryland 21740
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from
Hagerstown, MD
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Advanced Medical Imaging (MRI center)
Lincoln, Nebraska 68506
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from
Lincoln, NE
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Arthritis Center of Nebraska (X-ray center)
Lincoln, Nebraska 68516
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from
Lincoln, NE
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Physician Research Collaboration
Lincoln, Nebraska 68512
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mi
from
Lincoln, NE
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Paramount Medical Research & Consulting, Llc
Middleburg Heights, Ohio 44130
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mi
from
Middleburg Heights, OH
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Desert Medical Advances
Palm Desert, California 92260
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from
Palm Desert, CA
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Seattle Rheumatology Associates
Seattle, Washington 98104
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from
Seattle, WA
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Gastrointestinal Specialists, A.M.C.
Shreveport, Louisiana 71103
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mi
from
Shreveport, LA
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Louisiana Research Center, LLC
Shreveport, Louisiana 71103
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from
Shreveport, LA
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Shreveport Endoscopy Center, A.M.C.
Shreveport, Louisiana 71103
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mi
from
Shreveport, LA
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Arthritis Northwest
Spokane, Washington 99204
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mi
from
Spokane, WA
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Southwest Florida Clinical Research Center
Tampa, Florida 33609
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mi
from
Tampa, FL
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