A Study of Single Dose Inclacumab in Japanese Healthy Volunteers Compared to Caucasian Healthy Volunteers

Inclusion Criteria:

- Healthy male and female volunteers, 18 to 55 years of age, inclusive Healthy status
as defined by absence of evidence of any active or chronic disease following a
detailed medical and surgical history and a complete physical examination

- Japanese subjects must have Japanese parents and grandparents who were born in Japan

- Caucasian subjects must have Caucasian parents and grandparents

- Body mass index (BMI) 18 - 30 kg/m2 inclusive

Exclusion Criteria:

- Clinically significant abnormalities in laboratory test results (including positive
test for HIV, hepatitis B and/or C), vital signs or ECGs

- Any confirmed significant allergic reactions against any drug, or multiple allergies
(non-active hay fever is acceptable)

- Smokes more than 5 cigarettes per day during the three months prior to study conduct

- Participation in an investigational drug or device study within 30 days or 5
half-lives prior to screening

- Positive test for drugs of abuse

- Any suspicion of or history of alcohol and/or other substance abuse or addiction

- Pregnant or lactating women