Pain Control After Cardiac Surgery Using Intravenous Acetaminophen
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Chronic Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 4/21/2016 |
| Start Date: | March 2013 |
| End Date: | December 2015 |
Evaluate the efficacy of IV acetaminophen; compared to a placebo, in reducing opioid
consumption and/or pain intensity scores after cardiac surgery.
consumption and/or pain intensity scores after cardiac surgery.
Inclusion Criteria:
- - Males or females 18 years of age or older.
- Non-emergency cardiac surgery via a midline sternotomy.
Exclusion Criteria:
1. Redo cardiac surgery.
2. Combined CABG (Coronary Artery Bypass Graft)& valve replacement, multiple valve
replacements, Ascending aortic or aortic arch surgery.
3. Weight < 50 Kg or Body mass index > 38 kg/m2.
4. Left ventricle EF ¡Ü 35% ,Right ventricular moderate or severe dysfunction.
5. Severe (3-4 +) Tricuspid Regurgitation.
6. Recent stroke (within 6 months).
7. Severe lung disease requiring home O2 therapy.
8. Preoperative renal insufficiency (Creatinine > 2.0) or on dialysis.
9. History of liver cirrhosis or active liver disease.
10. Chronic pain conditions controlled by preoperative opioid administration.
11. Known allergy to acetaminophen or fentanyl.
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