Chlorthalidone Compared to Hydrochlorothiazide on Endothelial Function



Status:Completed
Conditions:High Blood Pressure (Hypertension)
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:19 - Any
Updated:3/16/2015
Start Date:March 2013
End Date:August 2015
Contact:Tammy L Burns, PharmD
Email:tammyburns@creighton.edu
Phone:402-280-4566

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Trial Summary
Trial Overview
Inclusion Criteria

The Effect of Chlorthalidone Compared to Hydrochlorothiazide on Endothelial Function in Hypertensive Patients: A Pilot Study

Chlorthalidone will result in improved endothelial function compared to hydrochlorothiazide
as measured by flow mediated vasodilatation.

This is a randomized, double-blind, crossover study to evaluate chlorthalidone and
hydrochlorothiazide and their effects on endothelial function in hypertensive patients.
Subjects will receive chlorthalidone 12.5 mg, hydrochlorothiazide 25 mg, and placebo each
for 4 weeks with a 1 week washout between study periods. Sequence of study drugs will be
randomized. Flow mediated vasodilatation will be measured at baseline and after each
treatment period.

Inclusion Criteria:

- Age 19 or older

- Diagnosis of hypertension

- Current blood pressure > 120/80 mm Hg

Exclusion Criteria:

- Use of a thiazide-type diuretic within the last 1 month

- Known allergy to any study medications

- History of gout or hyperuricemia

- SCr >/= 1.8 mg/dl or CrCl < 25 ml/min

- Pregnancy or breastfeeding or planning to become pregnant during study period

- Dementia or cognitive impairment

- Hypokalemia

- Acute coronary syndrome or stroke within 6 months

- Current use of sildenafil, tadalafil, or vardenafil
We found this trial at
1
site
Creighton University
2500 California Plaza
Omaha, Nebraska 68102
(402) 280-2700
Creighton University Creighton University, located in Omaha, Neb., offers a top-ranked education in the Jesuit...
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