Validation of an RLIP76 Assay in Humans
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Endocrine, Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | December 2012 |
Validation of RLIP76 Assay and Exploratory Study of RLIP76 Correlation Among Patients With Type 2 Diabetes and Metabolic Syndrome
The current proposal extends work done in mouse models evaluating the consistency of
measuring RLIP76 in a clinical cohort (Aim 1) by using guidelines provided by the NIH for
validating biomarkers. We will also proceed to estimate the effect size of a potential
correlation of RLIP76 with standard MsY treatment measures such as hgbA1c, LDL, and
triglyceride levels in a longitudinal prospective study ( Aim 2) that will follow a cohort
of patients with MsY who seek care at the City of Hope Endocrine clinic over a 12 month
period..
measuring RLIP76 in a clinical cohort (Aim 1) by using guidelines provided by the NIH for
validating biomarkers. We will also proceed to estimate the effect size of a potential
correlation of RLIP76 with standard MsY treatment measures such as hgbA1c, LDL, and
triglyceride levels in a longitudinal prospective study ( Aim 2) that will follow a cohort
of patients with MsY who seek care at the City of Hope Endocrine clinic over a 12 month
period..
Inclusion Criteria:
- Registered patient of City of Hope and followed in the Endocrine Clinic. Must have
documentation of a diagnosis of diabetes identified by the problem list in the
patient's electronic health record.
- Must demonstrate features of MsY by possessing any of the following characteristics
and/or receiving treatment for diabetes, hyperlipidemia, and/or hypertriglyceridemia.
- Central obesity: waist circumference ≥ 102 cm or 40 inches (male), ≥ 88 cm or 36
inches (female)
- Dyslipidemia: TG ≥ 1.7 mmol/L (150 mg/dl)
- Dyslipidemia: HDL-C < 40 mg/dL (male), < 50 mg/dL (female)
- Blood pressure ≥ 130/85 mmHg
- Fasting plasma glucose ≥ 6.1 mmol/L (110 mg/dl)
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