Simultaneous FMRI and NIRS to Estimate Brain Cerebral Metabolism
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 40 |
| Updated: | 4/13/2015 |
| Start Date: | January 2013 |
| End Date: | January 2014 |
Multi-Modal fMRI/NIRS for Estimation of CMRO2 for Neuroimaging Studies of Drug Abuse and Psychiatric Illness Problems
The principal advantages of functional magnetic resonance imaging (fMRI) with
blood-oxygenation- level-dependent (BOLD) contrast for studying brain function are:
non-invasiveness, ubiquitous availability, relatively high spatiotemporal resolution, and
the ability to map function over the entire brain. Thus, BOLD fMRI is the most widely
applied technology to study healthy brain function and pathophysiology associated with
disease. In studies of drug abuse and psychiatric illness though, normal assumptions mapping
BOLD signals to neurometabolism may be violated. Generally, these effects are ignored,
resulting in large study-to-study variability.
Quantitative fMRI (qfMRI) measures metabolism directly and is more suitable for studies of
drug abuse and psychiatric illness. However, qfMRI is too complex for routine use. Cerebral
metabolism during brain activation during visual stimulation measured with a new fMRI
approach that is simple enough for clinical applications will be compared to CMRO2
activation measured using standard qfMRI.
blood-oxygenation- level-dependent (BOLD) contrast for studying brain function are:
non-invasiveness, ubiquitous availability, relatively high spatiotemporal resolution, and
the ability to map function over the entire brain. Thus, BOLD fMRI is the most widely
applied technology to study healthy brain function and pathophysiology associated with
disease. In studies of drug abuse and psychiatric illness though, normal assumptions mapping
BOLD signals to neurometabolism may be violated. Generally, these effects are ignored,
resulting in large study-to-study variability.
Quantitative fMRI (qfMRI) measures metabolism directly and is more suitable for studies of
drug abuse and psychiatric illness. However, qfMRI is too complex for routine use. Cerebral
metabolism during brain activation during visual stimulation measured with a new fMRI
approach that is simple enough for clinical applications will be compared to CMRO2
activation measured using standard qfMRI.
Healthy subjects will undergo a single imaging session. During the imaging session, fMRI and
simultaneous near-infrared spectroscopy measurements will be made during visual stimulation
(e.g., viewing a flashing checkerboard). This is a methods development study focused on
comparing a new method for estimating CMRO2 associated with brain activation with the
standard fMRI approach for estimating CMRO2.
simultaneous near-infrared spectroscopy measurements will be made during visual stimulation
(e.g., viewing a flashing checkerboard). This is a methods development study focused on
comparing a new method for estimating CMRO2 associated with brain activation with the
standard fMRI approach for estimating CMRO2.
Inclusion Criteria:
- Male or female
- 18 to 40 years old
- Physically healthy by self-report
Exclusion Criteria:
Diagnosis of current drug abuse/dependence, including nicotine, as assessed by DSM-IV
criteria
- Current diagnosis of Axis I disorder using DSM-IV criteria, or any Axis I disorder
within past 5 years
- Current daily use of antipsychotic, antidepressant, or other psychoactive
prescription drug, as well as daily use of non-prescription drugs
- Life threatening or unstable medical illness, or one that can create marked change in
mental state
- Heavy caffeine use (greater than 300 mg on a regular, daily basis)
- History of seizure disorder
- Subjects that report any history or current major medical illness (cardiovascular,
pulmonary, psychiatric, or neurological disorders)
- Subjects who have metal in their body, suffer from claustrophobia or women who are
pregnant or currently breast-feeding cannot participate in this research study.
- Additional MR exclusion criteria may include people with:
- Cardiac pacemakers
- Metal clips on blood vessels (also called stents)
- Artificial heart valves
- Artificial arms, hands, legs, etc.
- Brain stimulator devices
- Implanted drug pumps
- Ear implants
- Eye implants or known metal fragments in eyes
- Exposure to shrapnel or metal filings (wounded in military combat, sheet metal
workers, welders, and others)
- Other metallic surgical hardware in vital areas
- Certain tattoos with metallic ink (subjects are asked to inform research staff if
they have a tattoo)
- Metal Containing Intrauterine Devices (IUDs).
- Certain transdermal (skin) patches such as Transderm Scop (scopolamine for motion
sickness), or Ortho Evra (birth control).
Enrollment:
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