Study of Using Long Acting Antihistamine to Treat Opioid Induced Itching
| Status: | Terminated |
|---|---|
| Conditions: | Allergy |
| Therapuetic Areas: | Otolaryngology |
| Healthy: | No |
| Age Range: | 6 - 18 |
| Updated: | 10/12/2018 |
| Start Date: | September 2014 |
| End Date: | November 2017 |
Effect of Long Acting Antihistamine on Opioid- Induced Pruritus: A Double-blind Placebo Controlled Study
The purpose of this study is determine if long acting antihistamine like cetirizine can help
with itching induced by opioid pain medications.
with itching induced by opioid pain medications.
Inclusion Criteria:
- Children age 6-18yrs on opioids who develop pruritus and are willing to participate in
the study
Exclusion Criteria:
- Children with history of chronic urticaria
- Children with other chronic pruritic condition like eczema, contact dermatitis,
psoriasis
- Children with known hypersensitivity to cetirizine/zyrtec
- Children on H1 antihistamine like diphenhydramine, hydroxyzine, cetirizine,
loratadine, fexofenadine, chlorpheniramine within the last 7days prior to
randomization
- Children who have received Ondansetron within 24hrs prior to randomization
- Children who are on Tricyclic antidepressants
- Children who are unwilling or unable to swallow the capsule.
- Children with chronic liver or kidney disease
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