Magnetic Resonance & Optical Spectroscopy Validation

Primary Study Objective:

To evaluate the reproducibility of acquiring multi-nuclear data on a new 3T Philips Magnet in
conjunction with Optical Spectroscopy.

Inclusion Criteria:

- Male or female

- Age 18 - 89

- Healthy (self assessed)

- Weight under 350lbs

- Able to walk 50 yards without stopping

- Able to travel to hospital for study visits

- Able to follow a 3-step command

- Able to remain in magnetic resonance (MR) scanner for up to 2 hours

Exclusion Criteria:

- Have internal metal medical devices, including cardiac pacemakers, aortic or cerebral
aneurysm clips, artificial heart valves, ferromagnetic implants, shrapnel, wire
sutures, joint replacements, bone or joint pins/rods/screws, metal fragments in your
eye, or non-removable jewelry such as rings.

- Are unwilling or unable to complete the imaging procedures for the duration of the
magnetic resonance imaging (MRI) scan due to claustrophobia or other reason.

- Serious mental illness that might preclude subject's ability to comply with study
treatment

- Are pregnant or plan on becoming pregnant in the next 8 weeks.

- History of deep vein thrombosis (DVT) or pulmonary embolism (PE)

- Varicose Veins

- Known genetic factor (Factor V Leiden, etc.) or hypercoagulable state, including
cancer, leukemia - such as chronic myelocytic leukemia (CML), hemoglobinopathies -
such as sickle-cell disease and multiple myeloma and other proteinopathies.

- Diagnosed peripheral arterial or vascular disease

- Family history of primary DVT or PE

- Peripheral neuropathy

- History of chronic venous stasis or lower extremity edema

- Female taking hormonal birth control (oral or otherwise) AND smoker