Tofacitinib Ointment For Chronic Plaque Psoriasis



Status:Completed
Conditions:Psoriasis
Therapuetic Areas:Dermatology / Plastic Surgery
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:May 2013
End Date:September 2014

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A Phase 2b, Multi-site, Randomized, Double-blind, Vehicle-controlled, Parallel-group Study Of The Efficacy, Safety, Local Tolerability And Pharmacokinetics Of 2 Dose Strengths And 2 Regimens Of Tofacitinib Ointment In Subjects With Chronic Plaque Psoriasis.

The study is beng done to test if tofacitinib ointment is safe and effective for people with
plaque psoriasis. Two dose strengths of tofacitinib ointment (20 mg/g and 10 mg/g) applied
once or twice daily are being tested. The safety and effectiveness of tofacitinib ointment
used for 12 weeks will be compared to the safety and effectiveness of placebo ointment
(vehicle) used for 12 weeks.


Inclusion Criteria:

- Have mild, moderate or severe plaque psoriasis (psoriasis vulgaris) for at least 6
months prior to Baseline

- At Baseline, have plaque psoriasis covering 2% to 20% of total body surface area
(BSA) on the trunk and limbs (excluding palms, soles, and nails)

- If received certain treatments, should be off treatment for a minimum period of time
(washout)

Exclusion Criteria:

- Currently have non-plaque forms of psoriasis or drug-induced psoriasis

- Require treatment with or cannot stop medication(s) prohibited during the study

- Have certain laboratory abnormalities at Baseline

- Current or history of certain infections

- Females who are pregnant, breastfeeding, or are of childbearing potential not using
highly effective contraception
We found this trial at
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Arlington, Texas 76011
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800 Washington St
Boston, Massachusetts 02111
(617) 636-5000
Tufts Medical Center Tufts Medical Center is an internationally-respected academic medical center – a teaching...
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593 Eddy Street
Providence, Rhode Island 02903
401-444-4000
Rhode Island Hospital Founded in 1863, Rhode Island Hospital in Providence, RI, is a private,...
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4499 Medical Drive
San Antonio, Texas 78229
210-614-5557
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Alpharetta, Georgia 30022
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Atlanta, Georgia 30342
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Cincinnati, Ohio 45249
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Clinton Township, Michigan 48038
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Edmonton, Alberta
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Greer, South Carolina
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High Point, North Carolina 27262
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Hot Springs, Arkansas 71913
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Houston, Texas 77056
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Irvine, California 92697
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Johnston, Rhode Island 02919
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Los Angeles, California 90045
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Nashville, Tennessee 37203
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Newnan, Georgia 30263
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Orange Park, Florida 32073
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Portland, Oregon 97223
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Portland, Oregon 97210
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Rapid City, South Dakota 57702
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San Antonio, Texas 78229
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Tampa, Florida 33609
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West Dundee, Illinois 60118
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1 Medical Center Blvd
Winston-Salem, North Carolina 27157
336-716-2011
Wake Forest University Health Sciences Welcome to Wake Forest Baptist Medical Center, a fully integrated...
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