Tofacitinib Ointment For Chronic Plaque Psoriasis
| Status: | Completed |
|---|---|
| Conditions: | Psoriasis |
| Therapuetic Areas: | Dermatology / Plastic Surgery |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | May 2013 |
| End Date: | September 2014 |
A Phase 2b, Multi-site, Randomized, Double-blind, Vehicle-controlled, Parallel-group Study Of The Efficacy, Safety, Local Tolerability And Pharmacokinetics Of 2 Dose Strengths And 2 Regimens Of Tofacitinib Ointment In Subjects With Chronic Plaque Psoriasis.
The study is beng done to test if tofacitinib ointment is safe and effective for people with
plaque psoriasis. Two dose strengths of tofacitinib ointment (20 mg/g and 10 mg/g) applied
once or twice daily are being tested. The safety and effectiveness of tofacitinib ointment
used for 12 weeks will be compared to the safety and effectiveness of placebo ointment
(vehicle) used for 12 weeks.
plaque psoriasis. Two dose strengths of tofacitinib ointment (20 mg/g and 10 mg/g) applied
once or twice daily are being tested. The safety and effectiveness of tofacitinib ointment
used for 12 weeks will be compared to the safety and effectiveness of placebo ointment
(vehicle) used for 12 weeks.
Inclusion Criteria:
- Have mild, moderate or severe plaque psoriasis (psoriasis vulgaris) for at least 6
months prior to Baseline
- At Baseline, have plaque psoriasis covering 2% to 20% of total body surface area
(BSA) on the trunk and limbs (excluding palms, soles, and nails)
- If received certain treatments, should be off treatment for a minimum period of time
(washout)
Exclusion Criteria:
- Currently have non-plaque forms of psoriasis or drug-induced psoriasis
- Require treatment with or cannot stop medication(s) prohibited during the study
- Have certain laboratory abnormalities at Baseline
- Current or history of certain infections
- Females who are pregnant, breastfeeding, or are of childbearing potential not using
highly effective contraception
We found this trial at
30
sites
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Tufts Medical Center Tufts Medical Center is an internationally-respected academic medical center – a teaching...
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Rhode Island Hospital Founded in 1863, Rhode Island Hospital in Providence, RI, is a private,...
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Boston, Massachusetts 02114
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1 Medical Center Blvd
Winston-Salem, North Carolina 27157
Winston-Salem, North Carolina 27157
336-716-2011
Wake Forest University Health Sciences Welcome to Wake Forest Baptist Medical Center, a fully integrated...
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