Premature Ventricular Contractions (PVCs) and Blood Pressure Control



Status:Terminated
Conditions:High Blood Pressure (Hypertension), Women's Studies
Therapuetic Areas:Cardiology / Vascular Diseases, Reproductive
Healthy:No
Age Range:18 - 65
Updated:2/24/2019
Start Date:February 2013
End Date:June 2016

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Trial Summary
Trial Overview
Inclusion Criteria

The Effects of PVC Suppression on Blood Pressure Control in Patients With Frequent PVCs

The purpose of this study is to determine if reduction in premature ventricular contraction
(PVC) burden results in a decrease in blood pressure, sympathetic outflow, plasma
catecholamines and an improvement in baroreflex gain. Flecainide will be used for PVC
suppression in a randomized, double-blinded, crossover fashion.


Inclusion Criteria:

- Frequent symptomatic premature ventricular contractions (PVCs) (>10% of total QRSs on
a 24-hour Holter)

- Willingness to participate in research

Exclusion Criteria:

- Age > 65 years old

- Pacemaker implantation

- Implantable cardioverter defibrillator implantation requiring pacing

- Sick sinus syndrome

- Atrio-ventricular (AV) block

- Left ventricular dysfunction defined as left ventricular ejection fraction < 50%

- History of myocardial infarction or coronary artery disease

- Severe left ventricular hypertrophy (wall thickness > 1.5 cm by echocardiography
performed within 3 months from enrollment)

- Severe liver dysfunction

- Creatinine clearance of 35 mL/min/1.73 square meters or less

- Pregnancy

- Known hypersensitivity to the drug

- QRS duration > 120 ms

- Recent change in blood pressure medication within 30 days of enrollment
We found this trial at
1
site
University of Wisconsin
Madison, Wisconsin 53792
(608) 263-2400
Principal Investigator: Mohamed Hamdan, MD, MBA
Phone: 608-263-8005
University of Wisconsin In achievement and prestige, the University of Wisconsin–Madison has long been recognized...
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Madison, WI
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