Phase 1 Multicenter, Single Ascending Dose Study to Assess the Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Response of PE0139 Injection in Adult Subjects With Type 2 Diabetes Mellitus

Inclusion Criteria:

- Willing and able to sign a written informed consent and follow all study-related
procedures;

- Male and female subjects at least 18 years of age;

- Male subjects and female subjects of childbearing potential must practice effective
contraception during the study and be willing and able to continue contraception for
30 days after their dose of study drug;

- Body mass index ≤45 kg/m2;

- Diagnosed with T2DM and who is currently taking a stable daily dose of a basal
insulin (Lantus) plus at least one oral antihyperglycemic agent at a stable dose for
3 months prior to screening.

Exclusion Criteria:

- Currently taking or have taken within 3 months prior to screening an approved or
investigational GLP-1 analogue/agonist (e.g., Victoza®) or pramlintide;

- Currently taking or have routinely taken, within 3 months prior to screening , a
short-acting insulin;

- Currently taking or have taken, within 3 months prior to screening, a long acting
insulin other than Lantus®;

- Known allergy to, or serious adverse effect caused by an approved, or investigational
insulin product or any of its components;

- Currently taking any of the following medications: thiazide or furosemide diuretics,
beta-blockers, estrogens or other hormonal replacement therapy, or other chronic
medications with known adverse effects on glucose tolerance levels unless the subject
has been on stable doses of such agents for at least 2 months prior to screening and
have no planned changes during the study period;

- History of recurrent severe hypoglycemia (more than 2 episodes within the last 6
months prior to randomization or hypoglycemic unawareness;

- Malignant disease defined as 1) any history of malignant melanoma or breast cancer
and/or 2) history of other types of cancer within the last 5 years prior to
screening;

- Unstable cardiovascular disease defined as one or more of the following: History of
stroke, transient ischemic attack, or myocardial infarction within 6 months prior to
screening; History of or currently have New York Heart Association Class III-IV heart
failure prior to screening; Uncontrolled/sustained hypertension; History or evidence
of long QT syndrome or mean triplicate 12-lead electrocardiogram demonstrating QT
interval;

- Clinically significant renal and/or hepatic dysfunction;

- Absolute requirement for corticosteroids or have received systemic steroids within 3
months prior to Randomization (V5, Day -1). Note: Use of inhaled or topical
corticosteroids will be permitted;

- Pregnant or lactating female subjects;

- Known history of or active alcohol abuse or use of illicit drugs within 1 year prior
to screening;

- Positive screening for human immunodeficiency virus antibodies, hepatitis B surface
antigen, or hepatitis C virus antibodies at V1;

- Participating in any other study and have received any other investigational
medication or device within 30 days prior to Visit 1.

- Other medical or psychiatric condition which, in the opinion of the Investigator,
would place the subject at increased risk.