Regular Swimming, Vascular Function, and Arthritis
| Status: | Completed |
|---|---|
| Conditions: | Arthritis, Osteoarthritis (OA) |
| Therapuetic Areas: | Rheumatology |
| Healthy: | No |
| Age Range: | 40 - 90 |
| Updated: | 3/16/2015 |
| Start Date: | January 2013 |
| End Date: | December 2014 |
| Contact: | Mohammed Alkatan |
| Email: | qatan81@gmail.com |
| Phone: | 512 568-2321 |
Effects of Swimming Exercise and Cycling Exercise Interventions on Vascular Function, Inflammation and Pain in Middle-aged and Older Adults With Osteoarthritis.
Hypothesis #1: The investigators hypothesize that both swimming training and cycling
training will demonstrate significant improvements in endothelium-mediated vasodilation and
central artery compliance in this population and that there will be no difference in the
magnitude of increases between the water-based and land-based exercise interventions.
Hypothesis #2: The investigators hypothesize that the improvements in endothelium-dependent
vasodilation and arterial compliance in response to exercise training interventions will be
related to the corresponding reductions in inflammatory biomarkers.
Hypothesis #3: The investigators hypothesize that both swimming exercise and cycling
exercise will improve functional capacities and disease progression in middle-aged and older
adults with osteoarthritis.
training will demonstrate significant improvements in endothelium-mediated vasodilation and
central artery compliance in this population and that there will be no difference in the
magnitude of increases between the water-based and land-based exercise interventions.
Hypothesis #2: The investigators hypothesize that the improvements in endothelium-dependent
vasodilation and arterial compliance in response to exercise training interventions will be
related to the corresponding reductions in inflammatory biomarkers.
Hypothesis #3: The investigators hypothesize that both swimming exercise and cycling
exercise will improve functional capacities and disease progression in middle-aged and older
adults with osteoarthritis.
Middle-aged and older men and women (40-90 years old) of all races and ethnic backgrounds
will serve as subjects after obtaining their written, informed consent. All the subjects
will have a radiological diagnosis of osteoarthritis according to American College of
Rheumatology criteria.
will serve as subjects after obtaining their written, informed consent. All the subjects
will have a radiological diagnosis of osteoarthritis according to American College of
Rheumatology criteria.
Inclusion Criteria:
- All the subjects will have a radiological diagnosis of osteoarthritis according to
American College of Rheumatology criteria
- Subjects will be sedentary (i.e., no regular physical activity for at least the prior
1 year)
Exclusion Criteria:
- Subjects with significant intima thickening,
- plaque formation, and/or characteristics of atherosclerosis.
- unstable cardiac or pulmonary diseases.
- joint replacement surgery in the previous year.
- intraarticular injection nor systemic steroids within previous 3 months.
- severe disabling co-morbidity that disallows receiving exercise therapy.
- excess alcohol use (>21 drinks/week).
- unwillingness to perform exercise.
- fear of water.
- mental incapability
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