Applying Speed of Processing Training to Individuals With Multiple Sclerosis
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Neurology, Multiple Sclerosis |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 8/9/2018 |
| Start Date: | November 2011 |
| End Date: | December 2018 |
Applying Speed of Processing Training (SPT) to Individuals With Multiple Sclerosis
This pilot study will document the efficacy of a behavioral intervention for Processing Speed
(PS) in Multiple Sclerosis (MS), Speed of Processing Training (SPT), which has been
successful used in the aging population in several studies. This study will (1) apply a
treatment protocol for PS impairments, well-validated in aging, to persons with MS with
impaired PS, and document its efficacy on standard neuropsychological (NP) tests (2) assess
the effectiveness of the intervention utilizing global measures of daily life, including an
objective measure (TIADL) (3) examine the long term impact of SPT. This study is unique in
that it will be the first to evaluate the efficacy of a highly-manualized structured
behavioral treatment for processing speed deficits in persons with MS utilizing the optimal
methodology for carrying out such studies, a randomized clinical trial. Given the prevalence
of PS deficits in the MS population and the significant impact such deficits have on everyday
functioning, public safety, and overall quality of life, the identification of an effective
intervention for PS deficits in MS could have a profound impact on the population and society
as a whole.
(PS) in Multiple Sclerosis (MS), Speed of Processing Training (SPT), which has been
successful used in the aging population in several studies. This study will (1) apply a
treatment protocol for PS impairments, well-validated in aging, to persons with MS with
impaired PS, and document its efficacy on standard neuropsychological (NP) tests (2) assess
the effectiveness of the intervention utilizing global measures of daily life, including an
objective measure (TIADL) (3) examine the long term impact of SPT. This study is unique in
that it will be the first to evaluate the efficacy of a highly-manualized structured
behavioral treatment for processing speed deficits in persons with MS utilizing the optimal
methodology for carrying out such studies, a randomized clinical trial. Given the prevalence
of PS deficits in the MS population and the significant impact such deficits have on everyday
functioning, public safety, and overall quality of life, the identification of an effective
intervention for PS deficits in MS could have a profound impact on the population and society
as a whole.
Inclusions:
- diagnosis of Multiple Sclerosis
- fluent in English
- processing speed impairment (based on evaluation).
Exclusions:
- currently taking steroids and /or benzodiazepines
- prior stroke or neurological disease
- history of significant psychiatric illness (for example, bipolar disorder,
schizophrenia, or psychosis) or a current diagnosis of Major Depressive Disorder,
Schizophrenia, Bipolar Disorder I or II
- significant alcohol or drug abuse history
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