Phase Analysis and Obstructive CAD on Rubidium PET
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 90 |
| Updated: | 5/5/2014 |
| Start Date: | October 2013 |
| End Date: | September 2014 |
| Contact: | Fabio Esteves, MD |
| Email: | festeve@emory.edu |
| Phone: | 404-712-4843 |
Regional and Global Left Ventricular Mechanical Dyssynchrony in the Diagnosis of Obstructive Coronary Artery Disease on Rest and Regadenoson Stress Rubidium Myocardial Perfusion PET
Rubidium myocardial perfusion PET is an imaging test used to diagnose patients with abnormal
blood flow to the heart secondary to narrowing of the heart vessels.
Phase analysis is a computer method that is applied after the PET test is done. It is used
to determine when a region of the heart contracts relative to other heart regions in the
heart beating cycle. Initial data suggest that regions of the heart with abnormal blood flow
change the pattern of contraction from rest to stress conditions. That is, regions of the
heart with abnormal blood supply become dyssynchronous when compared to the normal regions
of the heart.
This study will investigate whether phase analysis may aid the visual interpretation of
rubidium myocardial perfusion PET studies by determining the areas of the heart that are not
beating in synchrony with the normal heart regions. This information will be used as a proxy
for poor blood supply. The gold standard will be coronary angiography by which the percent
narrowing of the heart vessels is assessed.
blood flow to the heart secondary to narrowing of the heart vessels.
Phase analysis is a computer method that is applied after the PET test is done. It is used
to determine when a region of the heart contracts relative to other heart regions in the
heart beating cycle. Initial data suggest that regions of the heart with abnormal blood flow
change the pattern of contraction from rest to stress conditions. That is, regions of the
heart with abnormal blood supply become dyssynchronous when compared to the normal regions
of the heart.
This study will investigate whether phase analysis may aid the visual interpretation of
rubidium myocardial perfusion PET studies by determining the areas of the heart that are not
beating in synchrony with the normal heart regions. This information will be used as a proxy
for poor blood supply. The gold standard will be coronary angiography by which the percent
narrowing of the heart vessels is assessed.
Inclusion Criteria:
- Male or female patients
- referred for myocardial perfusion imaging for suspected obstructive CAD
- 18 years of age or older.
Exclusion Criteria:
- Contraindications to regadenoson radionuclide imaging including severe reactive
airway disease, unstable crescendo angina, high grade AV block, caffeine within 24
hours
- Documented prior myocardial infarction
- Severe claustrophobia
- Patients who may be pregnant.
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