Frailty Assessment Before Cardiac Surgery & Transcatheter Interventions

Status:	Completed
Conditions:	Cardiology
Therapuetic Areas:	Cardiology / Vascular Diseases
Healthy:	No
Age Range:	70 - Any
Updated:	3/16/2015
Start Date:	January 2012
End Date:	December 2015
Contact:	Amanda Trnkus, MSc
Email:	amanda.trnkus@epi.jgh.mcgill.ca
Phone:	514 340-8222

Frailty is a state of decreased physiologic reserves and vulnerability to stressors.
Several tools exist to measure frailty, some based on physical tests and others on
questionnaires, yet there is no agreement on which tool to recommend. This multi-center
prospective cohort study is aimed at comparing various frailty assessment tools to determine
which best predicts death or major complications after cardiac surgery or transcatheter
intervention. The population of interest is elderly patients with severe aortic stenosis
undergoing surgical or transcatheter aortic valve replacement. The frailty assessment tools
under investigation include composite frailty scales, physical performance tests, muscle
mass, and biomarker expression. The overall objective is to improve our ability to predict
risk by measuring frailty using the optimal tool in elderly cardiovascular patients.

Inclusion Criteria:

1. Age ≥70 years (a site-specific substudy at the JGH will enroll ages ≥21 years)

2. Severe AS

3. Referred for surgical or transcatheter AVR (with or without concomitant
revascularization)

4. Signed informed consent

Exclusion Criteria:

1. Emergency surgery

2. Clinical instability: decompensated heart failure, active ischemia, unstable vital
signs

3. Severe neuropsychiatric impairment

4. Not English or French speaking

5. Replacement of >1 valve or aortic surgery

We found this trial at

sites

Duke Univ Med Ctr

2301 Erwin Rd
Durham, North Carolina 27710

919-684-8111